Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Productos de "Ubiquitinación"
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DUB-IN-3
CAS:DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Fórmula:C16H9N5OPureza:99.34%Forma y color:SolidPeso molecular:287.28Ref: TM-T11112
1mg137,00€2mg188,00€5mg325,00€10mg465,00€25mg743,00€50mg1.035,00€100mg1.406,00€500mg2.802,00€1mL*10mM (DMSO)341,00€USP30 inhibitor 18
CAS:USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Fórmula:C26H28FN3O4SPureza:99.03%Forma y color:SolidPeso molecular:497.58Ref: TM-T36682
1mg144,00€5mg298,00€10mg472,00€25mg753,00€50mg1.074,00€100mg1.444,00€500mg2.822,00€1mL*10mM (DMSO)325,00€WS-383
CAS:WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).Fórmula:C18H21Cl2N9S2Pureza:98.46%Forma y color:SolidPeso molecular:498.46Ref: TM-T13349
1mg46,00€2mg58,00€5mg87,00€10mg144,00€25mg283,00€50mg558,00€100mg797,00€500mg1.634,00€1mL*10mM (DMSO)97,00€Ginkgolic Acid
CAS:Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.Fórmula:C22H34O3Pureza:98.69% - 99.9%Forma y color:White PowderPeso molecular:346.5P005091
CAS:P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Fórmula:C12H7Cl2NO3S2Pureza:99.53% - 99.87%Forma y color:SolidPeso molecular:348.22MSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Fórmula:C29H29F3N2Forma y color:SolidPeso molecular:462.55CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].Fórmula:C24H24N6OPureza:98.5%Forma y color:SoildPeso molecular:412.49Smurf1-IN-1
CAS:Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacyFórmula:C24H29ClN6O2Pureza:98%Forma y color:SolidPeso molecular:468.98DUB-IN-1
CAS:DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Fórmula:C20H11N5OPureza:98.33% - 98.96%Forma y color:SolidPeso molecular:337.33Ref: TM-T11110
1mg65,00€5mg116,00€10mg183,00€25mg353,00€50mg495,00€100mg652,00€200mg895,00€1mL*10mM (DMSO)128,00€MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Fórmula:C30H37N3O4SPureza:98.46%Forma y color:SolidPeso molecular:535.7Ref: TM-T12024
1mg43,00€5mg87,00€10mg144,00€25mg283,00€50mg454,00€100mg655,00€500mg1.454,00€1mL*10mM (DMSO)120,00€I-138
CAS:I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Fórmula:C26H23F3N6OPureza:99.41%Forma y color:SolidPeso molecular:492.5Ref: TM-T73560
1mg188,00€2mg255,00€5mg369,00€10mg597,00€25mg1.121,00€50mg1.700,00€100mg2.205,00€1mL*10mM (DMSO)425,00€Cbl-b-IN-11
CAS:Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) ofFórmula:C31H35F5N6OPureza:98%Forma y color:SolidPeso molecular:602.64EOAI3402143
CAS:EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Fórmula:C25H28Cl2N4O3Pureza:98.09%Forma y color:SolidPeso molecular:503.42Ref: TM-T11209
1mg66,00€5mg144,00€10mg227,00€25mg445,00€50mg717,00€100mg1.064,00€1mL*10mM (DMSO)160,00€ML240
CAS:ML240 is a selective, ATP-competitive p97 inhibitor.Fórmula:C23H20N6OPureza:100% - 99.66%Forma y color:SolidPeso molecular:396.44Ref: TM-T3535
1mg38,00€5mg81,00€10mg116,00€25mg205,00€50mg329,00€100mg528,00€200mg752,00€1mL*10mM (DMSO)88,00€STD1T
CAS:STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.Fórmula:C19H19N3O4S2Pureza:98.77%Forma y color:SolidPeso molecular:417.5OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Fórmula:C22H16ClFN2O4Pureza:98.59%Forma y color:SoildPeso molecular:426.83USP7/USP47 inhibitor
CAS:USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,Fórmula:C18H11Cl2N3O3S3Pureza:97.98% - 98.5%Forma y color:SolidPeso molecular:484.4Ref: TM-T4338
1mg43,00€5mg92,00€10mg160,00€25mg329,00€50mg547,00€100mg905,00€500mg1.786,00€1mL*10mM (DMSO)99,00€ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Fórmula:C23H25ClN4OPureza:99.91% - 99.96%Forma y color:SolidPeso molecular:408.92FT671
CAS:FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).Fórmula:C24H23F4N7O3Pureza:98%Forma y color:SolidPeso molecular:533.48ML364
CAS:ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.Fórmula:C24H18F3N3O3S2Pureza:100% - 99.92%Forma y color:SolidPeso molecular:517.54
