Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Productos de "Ubiquitinación"
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DKM 2-93
CAS:DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).Fórmula:C11H14ClNO3Pureza:98.37%Forma y color:SolidPeso molecular:243.69USP25/28 inhibitor AZ1
CAS:USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.Fórmula:C17H16BrF4NO2Pureza:99.79% - 99.79%Forma y color:SolidPeso molecular:422.21Ref: TM-T7685
1mg35,00€5mg70,00€10mg97,00€25mg210,00€50mg321,00€100mg472,00€500mg1.035,00€1mL*10mM (DMSO)78,00€SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFórmula:C16H8N2O3Pureza:99.75%Forma y color:SolidPeso molecular:276.25Ref: TM-T12926
1mg94,00€2mg137,00€5mg224,00€10mg339,00€25mg560,00€50mg810,00€100mg1.121,00€500mg2.232,00€IU1
CAS:IU1 是一种可逆的特异性人类 USP14 蛋白酶体抑制剂,可以穿透细胞,IC50为 4.7 μM。Fórmula:C18H21FN2OPureza:98% - 99.30%Forma y color:SolidPeso molecular:300.37CB-5083
CAS:CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Fórmula:C24H23N5O2Pureza:100% - 99.92%Forma y color:SolidPeso molecular:413.47Ref: TM-T6796
1mg46,00€2mg59,00€5mg87,00€10mg137,00€25mg298,00€50mg469,00€100mg687,00€500mg1.444,00€1mL*10mM (DMSO)97,00€LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Fórmula:C15H10N2O4SPureza:92.78%Forma y color:SolidPeso molecular:314.32Ubiquitination-IN-1
CAS:Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).Fórmula:C21H14F3N3O2SPureza:98.36% - 99.71%Forma y color:SolidPeso molecular:429.42Ref: TM-T13244
5mg70,00€10mg96,00€25mg168,00€50mg279,00€100mg418,00€500mg938,00€1mL*10mM (DMSO)77,00€Cbl-b-IN-6
CAS:Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (Fórmula:C30H32F5N5OPureza:98%Forma y color:SolidPeso molecular:573.6GNE-6640
CAS:GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).Fórmula:C20H18N4OPureza:98.64%Forma y color:SolidPeso molecular:330.38Ref: TM-T5461
1mg70,00€2mg92,00€5mg153,00€10mg250,00€25mg535,00€50mg772,00€100mg1.074,00€1mL*10mM (DMSO)166,00€GSK2643943A
CAS:GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Fórmula:C17H12FN3Pureza:97.09%Forma y color:SolidPeso molecular:277.3NSC232003
CAS:NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.Fórmula:C6H7N3O3Pureza:97.72%Forma y color:SolidPeso molecular:169.14TAS4464 hydrochloride
CAS:TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).Fórmula:C21H24ClFN6O6SPureza:98.3% - 98.61%Forma y color:SolidPeso molecular:542.97Ref: TM-T13090
1mg66,00€5mg144,00€10mg227,00€25mg455,00€50mg753,00€100mg1.301,00€1mL*10mM (DMSO)167,00€USP28-IN-4
CAS:USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Fórmula:C22H18Cl2N2O3SPureza:98.48%Forma y color:SolidPeso molecular:461.36NSC799462
NSC799462, a triazole inhibitor, specifically targets p97 ATPase, exerting its effect by binding to a designated site on the p97 enzyme. This interaction induces localized structural alterations in p97, effectively inhibiting its ATPase activity with an IC 50 value of 15 nM.Fórmula:C30H32F2N6O3SForma y color:SolidPeso molecular:594.68COH000
CAS:COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).Fórmula:C25H25NO5Pureza:99.23%Forma y color:SolidPeso molecular:419.47Ref: TM-T5199
1mg188,00€5mg411,00€10mg593,00€25mg1.064,00€50mg1.501,00€100mg2.080,00€200mg2.832,00€1mL*10mM (DMSO)454,00€CYM5442
CAS:CYM5442 is an S1P agonist, targeting to Sphingosine.Fórmula:C23H27N3O4Pureza:96.65% - 97.57%Forma y color:SolidPeso molecular:409.48WSB1 Degrader 1
CAS:WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.Fórmula:C21H22N2O2Pureza:98.57%Forma y color:SolidPeso molecular:334.41Ref: TM-T9236
1mg52,00€5mg116,00€10mg182,00€25mg320,00€50mg449,00€100mg610,00€200mg822,00€1mL*10mM (DMSO)128,00€Cbl-b-IN-3
CAS:Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).Cost-effective and quality-assured.Fórmula:C30H34F3N5OPureza:98.99%Forma y color:SolidPeso molecular:537.62Cbl-b-IN-9
CAS:Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximalFórmula:C30H33F3N6O2Pureza:98%Forma y color:SolidPeso molecular:566.62USP7-IN-6
CAS:USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).Fórmula:C41H43N7O4SPureza:98%Forma y color:SolidPeso molecular:729.89
