Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Productos de "Ubiquitinación"
Ordenar por
USP8-IN-3
CAS:USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.Fórmula:C18H18F3N5O2SPureza:99.18%Forma y color:SolidPeso molecular:425.43Ref: TM-T67873
1mg35,00€5mg64,00€10mg97,00€25mg207,00€50mg329,00€100mg475,00€500mg938,00€1mL*10mM (DMSO)84,00€P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Fórmula:C12H9NO3S2Pureza:100%Forma y color:SolidPeso molecular:279.33UP158
CAS:UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Fórmula:C17H17ClN4O2Forma y color:SolidPeso molecular:344.8UC-764864
CAS:UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling inFórmula:C19H18N2OSPureza:99.3%Forma y color:SolidPeso molecular:322.42Subasumstat
CAS:Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.Fórmula:C25H28ClN5O5S2Pureza:97.02% - 98.22%Forma y color:SolidPeso molecular:578.1dCeMM3
CAS:dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.Fórmula:C14H11ClN4OSPureza:98.48% - 99.19%Forma y color:SolidPeso molecular:318.78BI8626
CAS:BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cellsFórmula:C25H28N8Pureza:98.66%Forma y color:SolidPeso molecular:440.54Ref: TM-T14569
1mg92,00€5mg188,00€10mg298,00€25mg502,00€50mg715,00€100mg938,00€1mL*10mM (DMSO)215,00€C527
CAS:C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Fórmula:C17H8FNO3Pureza:97.22%Forma y color:SolidPeso molecular:293.25IU1-248
CAS:IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Fórmula:C20H23N3O2Pureza:99.30%Forma y color:SolidPeso molecular:337.42Ref: TM-T9375
1mg49,00€5mg104,00€10mg169,00€25mg334,00€50mg472,00€100mg658,00€200mg930,00€1mL*10mM (DMSO)115,00€UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Fórmula:C30H32F2N6O3SPureza:98%Forma y color:SolidPeso molecular:594.68ML-792
CAS:ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.Fórmula:C21H23BrN6O5SPureza:99.32% - 99.82%Forma y color:SolidPeso molecular:551.41Ref: TM-T16102
1mg92,00€2mg119,00€5mg187,00€10mg274,00€25mg432,00€50mg590,00€100mg843,00€1mL*10mM (DMSO)236,00€Heclin
CAS:Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.Fórmula:C17H17NO3Pureza:94.99% - 99.25%Forma y color:SolidPeso molecular:283.32Ref: TM-T24136
1mg35,00€5mg70,00€10mg111,00€25mg205,00€50mg321,00€100mg512,00€200mg728,00€1mL*10mM (DMSO)77,00€GNE-6776
CAS:GNE-6776 is a selective USP7 inhibitor.Fórmula:C20H20N4O2Pureza:96.59% - 98.2%Forma y color:SolidPeso molecular:348.4Ref: TM-T4634
1mg81,00€5mg170,00€10mg273,00€25mg525,00€50mg753,00€100mg1.026,00€1mL*10mM (DMSO)187,00€USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).Fórmula:C22H23N3O3Pureza:99.35% - 99.81%Forma y color:SolidPeso molecular:377.44UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Fórmula:C20H15ClN2O5SForma y color:SolidPeso molecular:430.86SJB2-043
CAS:SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Fórmula:C17H9NO3Pureza:98.44%Forma y color:SolidPeso molecular:275.26TRAF6 peptide TFA
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA.Fórmula:C145H238N34O44·xC2HF3O2Pureza:98%Forma y color:SolidPeso molecular:3161.64 (free acid)Nutlin-3
CAS:Nutlin-3 is an MDM2 antagonist that inhibits MDM2-p53 interaction and activates p53. Nutlin-3 has antitumor activity. Cost-effective and quality-assured.Fórmula:C30H30Cl2N4O4Pureza:98.13% - 99.89%Forma y color:SolidPeso molecular:581.49Ref: TM-T2158
1mg37,00€5mg74,00€10mg97,00€25mg197,00€50mg301,00€100mg454,00€200mg650,00€1mL*10mM (DMSO)87,00€USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Fórmula:C22H18N4Pureza:98.2%Forma y color:SolidPeso molecular:338.41VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Fórmula:C23H17F2N3O6Pureza:98.53% - 99.91%Forma y color:SolidPeso molecular:469.39Ref: TM-T4067
1mg96,00€2mg155,00€5mg259,00€10mg406,00€25mg680,00€50mg938,00€100mg1.301,00€1mL*10mM (DMSO)265,00€
