Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Productos de "Ubiquitinación"
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Skp2 inhibitor 3
Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.Forma y color:Odour SolidCbl-b-IN-12
CAS:Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100Fórmula:C28H29F3N6O2Pureza:98%Forma y color:SolidPeso molecular:538.56ICCB-19 hydrochloride
CAS:ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.Fórmula:C12H22ClN3OSPureza:99.30%Forma y color:SolidPeso molecular:291.84Ref: TM-T8931L
5mg35,00€10mg52,00€25mg96,00€50mg145,00€100mg210,00€200mg313,00€500mg495,00€1mL*10mM (DMSO)35,00€NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Fórmula:C27H28N4O3S2Pureza:99.05% - 99.5%Forma y color:SolidPeso molecular:520.67IU1-47
CAS:IU1-47 是一种特异性 USP14抑制剂,IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5, IC50为 20 μM。Fórmula:C19H23ClN2OPureza:98.94%Forma y color:SolidPeso molecular:330.85Ref: TM-T15604
1mg35,00€5mg74,00€10mg127,00€25mg263,00€50mg467,00€100mg785,00€200mg1.074,00€1mL*10mM (DMSO)81,00€Indole-3-carbinol
CAS:Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinaseFórmula:C9H9NOPureza:100% - 97.06%Forma y color:SolidPeso molecular:147.17USP8-IN-1
CAS:USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].Fórmula:C18H21N5O3SPureza:98.01%Forma y color:SoildPeso molecular:387.46Ref: TM-T60146
1mg88,00€5mg187,00€10mg264,00€25mg464,00€50mg655,00€100mg944,00€1mL*10mM (DMSO)207,00€USP7-IN-1
CAS:USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Fórmula:C23H24ClN3O3Pureza:98.70%Forma y color:SolidPeso molecular:425.91Ref: TM-T13268
1mg97,00€5mg188,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)217,00€Direct Black 38
CAS:Direct Black 38 (Chlorazol Black E) is a black azo dye that is genotoxic and induces unplanned DNA synthesis in rat liver and bone marrow micronuclei.Fórmula:C34H25N9Na2O7S2Pureza:98%Forma y color:Grey-Black Powder Physical Description Gray-Black Microcrystals Or Black Powder (Ntp 1992)Peso molecular:781.73E3 ligase Ligand 36
CAS:E3 ligase Ligand 36 is an E3 ligase ligand that can be utilized for synthesizing PROTACs, such as PROTAC BRM/BRG1 degrader-1.Fórmula:C25H30N4O5SForma y color:SolidPeso molecular:498.6IMP-1710
CAS:IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Fórmula:C23H19N5OPureza:99.77%Forma y color:SolidPeso molecular:381.43Wu-5
CAS:Wu-5 is a potent USP10 inhibitor that inhibits FLT3 and AMPK pathways, promoting the breakdown of FLT3-ITD and inducing apoptosis.Fórmula:C15H13NO7SPureza:99.29%Forma y color:SoildPeso molecular:351.33M435-1279
CAS:M435-1279 is a UBE2T inhibitor. M435-1279 blocks UBE2T-mediated degradation of RACK1, leading to inhibit the hyperactivation of Wnt/β-catenin signaling pathway.Fórmula:C18H17N3O5S2Pureza:97.16%Forma y color:SolidPeso molecular:419.47Ref: TM-T9500
1mg37,00€5mg80,00€10mg114,00€25mg212,00€50mg316,00€100mg447,00€200mg628,00€1mL*10mM (DMSO)95,00€BC-1382
CAS:BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).Fórmula:C23H29N3O5SPureza:99.15% - 99.72%Forma y color:SolidPeso molecular:459.56Ref: TM-T8564
1mg88,00€5mg188,00€10mg279,00€25mg535,00€50mg772,00€100mg1.074,00€200mg1.444,00€1mL*10mM (DMSO)254,00€OTUB2-IN-1
OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).Fórmula:C19H18N2O6S2Pureza:98.19%Forma y color:SolidPeso molecular:434.49USP1-IN-2
CAS:USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.Fórmula:C26H22F4N6OPureza:99.60% - 99.88%Forma y color:SolidPeso molecular:510.486XL177A
CAS:XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.Fórmula:C48H57ClN8O5Pureza:98.75%Forma y color:SolidPeso molecular:861.47Ref: TM-T9122
1mg96,00€5mg187,00€10mg298,00€25mg507,00€50mg730,00€100mg1.026,00€1mL*10mM (DMSO)283,00€HBX 19818
CAS:HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).Fórmula:C25H28ClN3OPureza:98.76%Forma y color:SolidPeso molecular:421.96Ref: TM-T15464
1mg38,00€5mg85,00€10mg117,00€25mg187,00€50mg266,00€100mg373,00€200mg530,00€1mL*10mM (DMSO)94,00€E3 ligase Ligand 41
CAS:E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.Fórmula:C13H12ClF3N2O4Forma y color:SolidPeso molecular:352.69PR-619
CAS:PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.Fórmula:C7H5N5S2Pureza:100% - 99.10%Forma y color:SolidPeso molecular:223.28
