Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Productos de "Ubiquitinación"
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DUB-IN-2
CAS:Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.Fórmula:C15H9N5OPureza:98.96%Forma y color:SolidPeso molecular:275.26Ref: TM-T11111
1mg79,00€5mg172,00€10mg259,00€25mg518,00€50mg758,00€100mg1.103,00€200mg1.483,00€1mL*10mM (DMSO)182,00€RNF5 agonist 1
CAS:RNF5 agonist 1 (analog-1), a structural analog of the RNF5 inhibitor inh-02, is a potent RNF5 agonist. In CFBE41o- cells expressing F508del-CFTR, RNF5 agonist 1 enhances the ubiquitination of ATG4B.Fórmula:C22H18N4SForma y color:SolidPeso molecular:370.47NSC819701
NSC819701 is a triazole-based inhibitor of p97ATPase. It inhibits the activity of p97ATPase by binding to specific sites on p97.Fórmula:C30H32F2N8O3SForma y color:SolidPeso molecular:622.69P 22077
CAS:P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Fórmula:C12H7F2NO3S2Pureza:97.9% - 99.58%Forma y color:SolidPeso molecular:315.32ML-323
CAS:ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.Fórmula:C23H24N6Pureza:99.87% - 99.96%Forma y color:SolidPeso molecular:384.48Ref: TM-T1757
1mg89,00€5mg207,00€10mg331,00€25mg512,00€50mg775,00€100mg1.140,00€1mL*10mM (DMSO)245,00€UP12
CAS:UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.Fórmula:C23H16ClN3O3SForma y color:SolidPeso molecular:449.91DCN1-UBC12-IN-4
CAS:DCN1-UBC12-IN-4 (compound 5p) acts as an inhibitor of DCN1-UBC12, exhibiting an IC50 value greater than 10000 nM and possesses antitumor activity.Fórmula:C8H6ClN3SForma y color:SolidPeso molecular:211.67Siremadlin
CAS:Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.Fórmula:C26H24Cl2N6O4Pureza:97.77% - 99.30%Forma y color:SolidPeso molecular:555.412-D08
CAS:2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.Fórmula:C15H10O5Pureza:98.58% - 98.95%Forma y color:SolidPeso molecular:270.24USP28-IN-3
CAS:USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Fórmula:C23H20Cl2N2O3SPureza:99.85%Forma y color:SolidPeso molecular:475.39Cbl-b-IN-10
CAS:Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (Fórmula:C31H37F3N6OPureza:98%Forma y color:SolidPeso molecular:566.66Skp2 inhibitor 2
CAS:Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.Fórmula:C27H32N4OPureza:98%Forma y color:SolidPeso molecular:428.57Ethanolamine-Thalidomide-4-OH
CAS:Ethanolamine-Thalidomide-4-OH is an E3 ligase ligand-linker conjugate used in the synthesis of PROTACs, such as [PROTAC BTK Degrader-13].Fórmula:C15H15N3O5Forma y color:SolidPeso molecular:317.297USP5-IN-1
USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.Fórmula:C19H20ClN3O5SPureza:99.53%Forma y color:SoildPeso molecular:437.9PYZD-4409
CAS:PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.Fórmula:C14H7ClFN3O5Pureza:98.00%Forma y color:SolidPeso molecular:351.67Ref: TM-T16699
1mg38,00€5mg80,00€10mg120,00€25mg216,00€50mg354,00€100mg512,00€500mg1.093,00€1mL*10mM (DMSO)88,00€Cbl-b-IN-8
CAS:Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5Fórmula:C35H44F3N7O3Pureza:98%Forma y color:SolidPeso molecular:667.76FT827
CAS:FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.Fórmula:C27H28N6O5SPureza:98.76%Forma y color:SolidPeso molecular:548.61N106
CAS:N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.Fórmula:C17H14N4O3SPureza:98.75%Forma y color:SolidPeso molecular:354.38GS143
CAS:GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Fórmula:C28H19FN2O4Pureza:99.72%Forma y color:SolidPeso molecular:466.46Ref: TM-T25465
2mg38,00€5mg58,00€10mg92,00€25mg170,00€50mg259,00€100mg378,00€200mg548,00€1mL*10mM (DMSO)60,00€NAcM-OPT
CAS:NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM).Fórmula:C23H29Cl2N3OPureza:99.68%Forma y color:SolidPeso molecular:434.4
