Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase
- CDK
- Arrêt du cycle cellulaire
- Chk
- c-Myc
- Dynamine
- DYRK
- Ferroptose
- HSP
- Intégrine
- Kinésine
- KSP
- LIM Kinase
- Microtubules associés
- PKC
- PLK
- Rho
- ROCK
- Wee1
Affichez 11 plus de sous-catégories
Produits appartenant à la catégorie "Cycle cellulaire/point de contrôle"
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CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.43Gallium maltolate
CAS :Gallium maltolate is a ribonucleoside-diphosphate reductase inhibitor.Formule :C18H15GaO9Degré de pureté :99.67% - 99.75%Couleur et forme :SolidMasse moléculaire :445.03Pyridostatin TFA
CAS :Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-Formule :C37H35F9N8O11Degré de pureté :97.09% - 99.84%Couleur et forme :SolidMasse moléculaire :938.71TMX-2039
CAS :TMX-2039 is a pan-CDK inhibitor that targets cell cycle CDKs (CDK1, CDK2, CDK4, CDK5, and CDK6) and transcription CDKs (CDK7 and CDK9), with IC50 values of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5, and 25 nM, respectively. It serves as a ligand for the target protein in PROTAC applications.Formule :C17H20BrFN6O3SCouleur et forme :SolidMasse moléculaire :487.347Stigmatellin
CAS :Stigmatellin is an antibiotic derived from the cell mass of the myxobacterium, effective against yeasts (yeasts), filamentous fungi (filamentous fungi), and several Gram-positive bacteria (Gram-positive bacteria). Additionally, it serves as a potent inhibitor of photosynthetic electron (photosynthetic electron) transfer. Stigmatellin utilizes various sugars, polysaccharides, and acids from the citric acid cycle as substrates, inhibiting RNA and protein synthesis. It has two different inhibitory sites: one located on the reducing side of photosystem II and the other at the cytochrome b6/f complex. Stigmatellin holds potential for use in antimicrobial and photosynthesis research.Formule :C30H42O7Couleur et forme :SolidMasse moléculaire :514.65MGB-BP-3
CAS :MGB-BP-3 is a synthetic antibiotic with bactericidal activity that inhibits bacterial DNA replication and can be used to study recurrent C. difficile infections.Formule :C36H37N7O4Degré de pureté :97.06% - 98.92%Couleur et forme :SolidMasse moléculaire :631.72STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Degré de pureté :95% - 95%Couleur et forme :Odour Liquid2',3'-Dideoxyuridine
CAS :2',3'-Dideoxyuridine is a purine nucleoside analog with potential antitumor activity.Formule :C9H12N2O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :212.2WRN inhibitor 11
CAS :WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.Formule :C34H35ClF3N9O5Couleur et forme :SolidMasse moléculaire :742.15C16Y
CAS :C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Formule :C78H115N17O17Couleur et forme :SolidMasse moléculaire :1562.85EMD534085
CAS :EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).Formule :C25H31F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.535-Methylcytosine
CAS :5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA.Formule :C5H7N3ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :125.13SRI-29329
CAS :SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).Formule :C20H26ClN7Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :399.92Ref: TM-T8801
1mg92,00€5mg188,00€10mg306,00€25mg520,00€50mg748,00€100mg1.026,00€1mL*10mM (DMSO)215,00€3-AP
CAS :3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).Formule :C7H9N5SDegré de pureté :97.33% - 99.75%Couleur et forme :SolidMasse moléculaire :195.24Ref: TM-T1982
2mg39,00€5mg57,00€10mg69,00€25mg150,00€50mg264,00€100mg400,00€500mg909,00€1mL*10mM (DMSO)57,00€Human PD-L1 inhibitor V
CAS :Human PD-L1 Inhibitor V is a peptide that binds to the human PD-1 protein with an affinity characterized by a dissociation constant (Kd) of 3.32 μM, effectivelyFormule :C65H104N20O18SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1485.71T521
CAS :T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.Formule :C17H14FNO5S2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :395.43AZ5576
CAS :AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].Formule :C21H24FN3O3Degré de pureté :99.88%Couleur et forme :SoildMasse moléculaire :385.43Ref: TM-T60152
1mg35,00€5mg80,00€10mg113,00€25mg221,00€50mg331,00€100mg475,00€500mg938,00€1mL*10mM (DMSO)87,00€PROTAC CDK9 degrader-11
CAS :PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Formule :C39H48Cl2N10O5Couleur et forme :SolidMasse moléculaire :807.768SCH900776 (S-isomer)
CAS :SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Formule :C15H18BrN7Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :376.25Ref: TM-T3700
1mg49,00€2mg70,00€5mg96,00€10mg155,00€25mg264,00€50mg424,00€100mg627,00€1mL*10mM (DMSO)114,00€Senexin C
CAS :Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Formule :C28H27N5ODegré de pureté :97.91%Couleur et forme :SolidMasse moléculaire :449.55
