Produits biochimiques et réactifs

A synthetic peptide for use as a blocking control in assays to test for specificity of CDH4 antibody, catalog no. 70R-6191

Custom research peptide; min purity 95%.

Mouse monoclonal STAT4 antibody

BF 544 is a peptide that is used as a research tool. It has been shown to activate the ion channels in cells, which leads to changes in the membrane potential. BF 544 also interacts with antibodies and receptors, causing changes in ligand binding and protein interactions. This peptide can be used as an inhibitor for pharmacological studies of ion channels and membrane proteins.

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a secretase inhibitor that inhibits the enzyme that cleaves amyloid precursor protein (APP) to release beta-amyloid. It has been shown to prevent the formation of plaques in the brain and may be used to treat Alzheimer's disease. (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu has also been shown to inhibit the production of tumor necrosis factor alpha (TNFα), which is involved in inflammation and carcinogenesis. The drug has been shown to reduce myocardial infarct size by preventing cardiac cell death and reducing inflammation following a heart attack. It is also active against multiple types of cancer cells, including carcinoma cell lines and multidrug resistant cells.

Rabbit polyclonal Synaptotagmin 2 antibody

H-QPQPLPSPGVGGKN-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-QPQPLPSPGVGGKN-OH is provided at greater that >95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-QPQPLPSPGVGGKN-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-QPQPLPSPGVGGKN-OH at the technical inquiry form on this page

H-YLWNLLLYWGRELKN-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-YLWNLLLYWGRELKN-OH is provided at greater that >80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-YLWNLLLYWGRELKN-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-YLWNLLLYWGRELKN-OH at the technical inquiry form on this page

L-azidotryptophan CHA salt

Peptide H-GNNQQNY-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-GNNQQNY-OH include the following: Molecular dynamics simulations on the oligomer-formation process of the GNNQQNY peptide from yeast prion protein Sup35 Z Zhang, H Chen, H Bai , L Lai - Biophysical journal, 2007 - cell.comhttps://www.cell.com/biophysj/pdf/S0006-3495(07)71409-1.pdf Prion-like Aggregation of the Heptapeptide GNNQQNY into Amyloid Nanofiber Is Governed by Configuration Entropy Z Chen, X Xiao, L Yang, C Lian, S Xu - Journal of Chemical , 2023 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jcim.3c00370 Dual-functional, multi-targeting GNNQQNY-AIE conjugates as amyloid probes and amyloid modulators via amyloid cross-seeding principle Y Tang , D Zhang , X Gong - Advanced Functional , 2022 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202208022 Neglected hydrophobicity of dimethanediyl group in peptide self-assembly: a hint from amyloid-like peptide GNNQQNY and its derivatives Y Chen, Z Xing, D Liao, F Qiu - The Journal of Physical Chemistry , 2018 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jpcb.8b09220 Factors that affect the degree of twist in beta-sheet structures: a molecular dynamics simulation study of a cross-beta filament of the GNNQQNY peptide X Periole, A Rampioni, M Vendruscolo - The Journal of Physical , 2009 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/jp8078259 Binding modes of thioflavin T molecules to prion peptide assemblies identified by using scanning tunneling microscopy X Mao , Y Guo, C Wang , M Zhang, X Ma - ACS chemical , 2011 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/cn200006h Alternative packing modes leading to amyloid polymorphism in five fragments studied with molecular dynamics WM Berhanu , AE Masunov - Peptide Science, 2012 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/bip.21731 Infrared laser-induced amyloid fibril dissociation: a joint experimental/theoretical study on the GNNQQNY peptide T Kawasaki, VH Man , Y Sugimoto - The journal of , 2020 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jpcb.0c05385 Adsorption of amyloidogenic peptides to functionalized surfaces is biased by charge and hydrophilicity T John , GW Greene , NA Patil , TJA Dealey - Langmuir, 2019 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.langmuir.9b02063 Non-covalent complexes of the peptide fragment Gly-Asn-Asn-Gln-Gln-Asn-Tyr in the gas-phase. Photodissociative cross-linking, Born-Oppenheimer molecular SR Huang , Y Liu , F Tureček - Physical Chemistry Chemical Physics, 2019 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2019/cp/c8cp06893c HRMAS 1H NMR Conformational Study of the Resin-Bound Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup35 SB Andrey, ML Chan, WP Power - The Journal of Physical , 2010 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/jp909899w Molecular insight into the effects of enhanced hydrophobicity on amyloid-like aggregation S Paul , K Kumari, S Paul - The Journal of Physical Chemistry B, 2020 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jpcb.0c06000 Formation of nanostructures by peptides S Kumar Pachahara , C Subbalakshmi - Protein and Peptide , 2017 - ingentaconnect.comhttps://www.ingentaconnect.com/content/ben/cpps/2017/00000018/00000009/art00007 Dynamic nuclear polarization of amyloidogenic peptide nanocrystals: GNNQQNY, a core segment of the yeast prion protein Sup35p PCA van der Wel , KN Hu, J Lewandowski - Journal of the , 2006 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ja0626685 Solid-state NMR study of amyloid nanocrystals and fibrils formed by the peptide GNNQQNY from yeast prion protein Sup35p PCA van der Wel , JR Lewandowski - Journal of the American , 2007 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ja068633m Structural characterization of GNNQQNY amyloid fibrils by magic angle spinning NMR PCA van der Wel , JR Lewandowski , RG Griffin - Biochemistry, 2010 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/bi100077x Flexible structures and ligand interactions of tandem repeats consisting of proline, glycine, asparagine, serine, and/or threonine rich oligopeptides in proteins N Matsushima, H Yoshida, Y Kumaki - Protein and Peptide , 2008 - ingentaconnect.comhttps://www.ingentaconnect.com/content/ben/cpps/2008/00000009/00000006/art00005 Inhibition of GNNQQNY prion peptide aggregation by trehalose: a mechanistic view N Katyal , S Deep - Physical Chemistry Chemical Physics, 2017 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2017/cp/c7cp02912h Amyloid formation characteristics of GNNQQNY from yeast prion protein Sup35 and its seeding with heterogeneous polypeptides M Haratake, T Takiguchi, N Masuda, S Yoshida - Colloids and Surfaces B , 2017 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0927776516307159 Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association L Vitagliano , L Esposito , C Pedone - and biophysical research , 2008 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0006291X08019839 Thermodynamic analysis of structural transitions during GNNQQNY aggregation KL Osborne, M Bachmann - : Structure, Function, and , 2013 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/prot.24263 The Driving Forces of Peptide Aggregation: A Study of the Yeast Sup35 Prion Fragment GNNQQNY K Lebo - 2008 - dlib.bc.eduhttps://dlib.bc.edu/islandora/object/bc-ir:102342/datastream/PDF/download/citation.pdf Primary nucleation kinetics of short fibril-forming amyloidogenic peptides JA Luiken, PG Bolhuis - The Journal of Physical Chemistry B, 2015 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jpcb.5b05799 Prediction of a stable associated liquid of short amyloidogenic peptides JA Luiken, PG Bolhuis - Physical Chemistry Chemical Physics, 2015 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2015/cp/c5cp00284b Structural stability and dynamics of an amyloid-forming peptide GNNQQNY from the yeast prion sup-35 J Zheng , B Ma , CJ Tsai , R Nussinov - Biophysical journal, 2006 - cell.comhttps://www.cell.com/biophysj/pdf/S0006-3495(06)71793-3.pdf Supramolecular Structure and Stability of the GNNQQNY beta-Sheet Bilayer Filament: A Computational Study J Park, B Kahng , W Hwang - Summer , 2007 - asmedigitalcollection.asme.orghttps://asmedigitalcollection.asme.org/SBC/proceedings-abstract/SBC2007/779/331540 On cooperative effects and aggregation of GNNQQNY and NNQQNY peptides J Nochebuena , J Ireta - The Journal of Chemical Physics, 2015 - pubs.aip.orghttps://pubs.aip.org/aip/jcp/article/143/13/135103/826694 A multiscale approach to characterize the early aggregation steps of the amyloid-forming peptide GNNQQNY from the yeast prion sup-35 J Nasica-Labouze , M Meli , P Derreumaux - PLoS Computational , 2011 - journals.plos.orghttps://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002051 Inhibitory effect of hydrophobic fullerenes on the beta-sheet-rich oligomers of a hydrophilic GNNQQNY peptide revealed by atomistic simulations J Lei, R Qi , L Xie, W Xi , G Wei - RSC advances, 2017 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2017/ra/c6ra27608c Use of Short Amyloidogenic Peptides for Nanotechnology GM Guerra - nanopt.orghttps://www.nanopt.org/15Abstracts/2015_Guerra_Gabriela_gguerra@medicina.ulisboa.pt_NanoPT2015_Guerra_Gabriela.pdf GNNQQNY: Methodology for biophysical and structural understanding of aggregation G Burra , MB Maina , LC Serpell, AK Thakur - bioRxiv, 2022 - biorxiv.orghttps://www.biorxiv.org/content/10.1101/2022.01.01.474692.abstract Insights into the molecular mechanism behind solubilization of amyloidogenic polyglutamine-containing peptides G Burra , AK Thakur - Peptide Science, 2019 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/pep2.24094 Clustering and fibril formation during GNNQQNY aggregation: a molecular dynamics study B Szała-Mendyk, A Molski - Biomolecules, 2020 - mdpi.comhttps://www.mdpi.com/2218-273X/10/10/1362 Thermodynamics and kinetics of aggregation for the GNNQQNY peptide B Strodel , CS Whittleston , DJ Wales - Journal of the American , 2007 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ja075346p GNNQQNY-investigation of early steps during amyloid formation AS Reddy , M Chopra, JJ De Pablo - Biophysical journal, 2010 - cell.comhttps://www.cell.com/fulltext/S0006-3495(09)01750-0 A peptide study of the relationship between the collagen triple-helix and amyloid AS Parmar , AM Nunes, J Baum , B Brodsky - Biopolymers, 2012 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/bip.22070 Interplay of sequence, topology and termini charge in determining the stability of the aggregates of GNNQQNY mutants: a molecular dynamics study A Srivastava , PV Balaji - Plos one, 2014 - journals.plos.orghttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096660 Molecular events during the early stages of aggregation of GNNQQNY: An all atom MD simulation study of randomly dispersed peptides A Srivastava , PV Balaji - Journal of structural biology, 2015 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1047847715300757

Rat monoclonal IgG2b Isotype Control Fc fusion protein (PE)

A synthetic peptide for use as a blocking control in assays to test for specificity of UBE2L3 antibody, catalog no. 70R-3085

Tripeptides were prepared by means of coupling of N-Fmoc-N-methyl-D-leucine. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

ICEC0942 is a protein kinase inhibitor that inhibits the activity of transcription factors. It has been shown to have anticancer effects in laboratory studies and in clinical trials on patients with cancer. ICEC0942 was found to be effective at a dose of 0.3 mg/kg, which is lower than the doses typically used for chemotherapy drugs. ICEC0942 also has a low toxicity profile and does not cause DNA damage or cellular dysregulation, which are common side effects of other cancer therapies.

Rabbit polyclonal SPK antibody

Purified recombinant SIV mac251 p28 protein

H-LLLGLLAFLQYRRLR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LLLGLLAFLQYRRLR-OH is provided at greater that >80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LLLGLLAFLQYRRLR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LLLGLLAFLQYRRLR-OH at the technical inquiry form on this page

PGR antibody was raised in Mouse using a purified recombinant fragment of PGR(aa731-909) expressed in E. coli as the immunogen.

tPA Matched Pair antibody Set for ELISA