Hétérocycles azotés (N)

2,3-Dichloro-5-nitropyridine (2,3-DNP) is an antidiabetic drug that has been shown to improve insulin sensitivity in animals. It is a sample preparation reagent that can be used to validate the use of γ-aminobutyric acid (GABA) as a linker for the immobilization of proteins on solid supports. 2,3-DNP is also used as an adipose tissue marker to study obesity and insulin resistance. This drug has been shown to increase choline levels in the liver by inhibiting its export and increasing its synthesis by phosphorylation of serine hydroxymethyltransferase. 2,3-DNP also increases fatty acid synthesis by activating acetyl coenzyme A carboxylase and inhibiting carnitine palmitoyl transferase I. 2,3-DNP has also been shown to decrease food intake and body weight gain in db/db mice

Orotic acid hydrate is a synthetic compound that is designed to be a growth regulator. Orotic acid hydrate is synthesized by reacting the orotate with pyridoxine hydrochloride, followed by crystallizing the product. Hydrogen bonds form between the water molecules and fatty acids in the crystals of OA hydrate. These hydrogen bonds stabilize the crystal structure and allow for its use as a growth regulator. The stability of this molecule can also be attributed to its ability to form hydrogen bonds with other molecules such as α-tocopherol, calcium carbonate, and synthetic cannabinoids. Orotic acid hydrate has been shown to have an effect on cancer cells because it reacts with daunorubicin in solution and inhibits DNA synthesis, inhibiting cell growth.

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3,6-Dichloropyridazine-4-carboxylic acid is a compound that has been shown to have immunosuppressive properties. This molecule is able to inhibit the function of virus by inhibiting the production of proteins vital for cell division and also inhibits the synthesis of antibodies. 3,6-Dichloropyridazine-4-carboxylic acid was originally developed as a drug for the treatment of AIDS, but it was never marketed. This molecule has also been shown to have antiviral activity against HIV and influenza A virus and may be useful in treating other immunodeficiency diseases.

Piperic acid is a metal chelate that has synergistic effects with other antimicrobial agents. It can be used to treat infectious diseases and carcinoma. Piperic acid is a natural compound found in plants, fruits, and vegetables, which has been shown to inhibit drug transporter proteins P-glycoprotein (P-gp) in the mitochondrial membrane potential. This inhibits the transport of drugs from outside the cell into the mitochondrial membrane, which also prevents the production of reactive oxygen species.

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Applications 3-Benzyloxy[6-[2-(tert-Butyldimethylsilyloxy)ethyl]methylamino]pyridine (cas# 1076198-95-2) is a compound useful in organic synthesis.

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2,6-Di(1H-pyrazol-1-yl)pyridine is a stable, crystalline compound that has been synthesized. It has been shown to form coordination complexes with metal ions, such as copper and zinc. The molecular structure of 2,6-Di(1H-pyrazol-1-yl)pyridine consists of a pyrazole ring, two amide groups and three nitrogen atoms. This molecule also possesses functional groups that can be found in chlorophyll A. 2,6-Di(1H-pyrazol-1-yl)pyridine is soluble in organic solvents such as alcohols and acetone. It is an orange solid at room temperature with a melting point of about 170°C. The UV absorption spectrum for 2,6-Di(1H-pyrazol-1-yl)pyridine shows strong absorption at 260 nm with an extinction coefficient of 12200 M

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