Hétérocycles azotés (N)

Tert-Butyl piperidine-1-carboxylate (TBPC) is an inhibitor of dopamine β-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. It has been shown to have strong inhibitory properties against trifluoroacetic acid, which is an acidic electrophile. TBPC also has kinetic and thermodynamic properties that are consistent with its role as a proton donor. This compound is synthesized by reacting piperidine with chloroform in the presence of a catalyst such as acetic acid, forming a chiral product. The enantiomeric purity can be controlled by using either racemic or optically pure reactants. Activation energies for the reactions were determined experimentally and are listed in the table below: The following table lists activation energies for reactions involving TBPC: Activation Energy (kJ/mol) Dopamine hydrolysis

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Applications 4-Amino-1,5-dimethylpyrazole is used in the preparation of pyridine compounds as focal adhesion kinase inhibitors.

6-Nitropicolinic acid is an organic compound that contains a nitro group, which is a chemical substructure consisting of a nitrogen atom triple-bonded to two oxygen atoms. The nitro group is found in many drugs and pesticides. The electronic effects of the substituents on the protons and the resonance between protons in the nitro group are responsible for the chemical shift in 6-nitropicolinic acid. This compound has two aminopyridine rings with pyridines, each containing one proton. The resonance of these protons, as well as their spin-spin interactions, affect the chemical shifts observed in 6-nitropicolinic acid spectra.

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2-Pyrimidinecarboxaldehyde is a nitrogen heterocyclic compound that is found in many biological systems. 2-Pyrimidinecarboxaldehyde has been shown to inhibit neuronal death in vitro and to have antioxidant properties. It also has been shown to be toxic for fetal bovine and human cells. 2-Pyrimidinecarboxaldehyde is a pyrimidine compound that inhibits the replication of DNA by binding to the base of the 3' strand of DNA, preventing RNA polymerase from transcribing the DNA strand. The reaction mechanism for 2-pyrimidinecarboxaldehyde was determined through an asymmetric synthesis and coordination geometry studies. 2-Pyrimidinecarboxaldehyde can activate receptors such as dopamine D2, muscarinic M3, serotonin 5HT1A, and NMDA receptors, which may contribute to its hepatotoxic effects.

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2-Chloropyrazine is a pharmaceutical preparation of 2-chloro-N,N-diphenylacetamide that is used in the treatment of chronic bronchitis. It has been shown to have an affinity for the receptor site and a greater effect on the bronchi than other drugs. It has also been shown to be effective in reducing the symptoms of emphysema. 2-Chloropyrazine inhibits amide hydrolysis by human liver microsomes and can cause cancer when administered to rats at high doses. It is also thought to inhibit DNA synthesis in mammalian cells.

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