Hétérocycles azotés (N)

1-Methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid (1MDP) is a proton stabilizer that enhances the rate of reactions involving carboxylate anions. It is used in organic synthesis as a substrate for the generation of methylene carbanions and active methylene compounds. 1MDP has been shown to enhance the rate of reactions with metaperiodate in the presence of ultraviolet light and orotic acid, yielding uncharged products. 1MDP also has been shown to increase the stability of both aromatic and aliphatic carboxylates.

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6-Methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid is an organic compound that can be used as a cancer drug. 6-Methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid has been shown to inhibit the growth of cancer cells and is effective against certain types of cancer. 6MDA has been shown to bind to a pharmacophore in the cell membrane that is involved in cellular respiration, which leads to inhibition of protein synthesis and eventually cell death. It also inhibits bacterial growth by binding to the enzyme nitrate reductase or by directly inhibiting the enzymes involved in bacterial DNA synthesis. The drug is not active against bacteria that are resistant to organic acids, such as Staphylococcus aureus or Clostridium perfringens.

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Applications 2-(3-chlorophenyl)pyrimidine-4-carboxylic acid (cas# 1216604-60-2) is a useful research chemical.

2,4-Dichloro-6-methylpyridine is a synthetic compound that has been shown to induce apoptosis in human cancer cells. It is believed that this drug works by inducing DNA damage and subsequent cell death. 2,4-Dichloro-6-methylpyridine binds to sulfur atoms in the pyridine nucleotide cycle and prevents the enzyme from functioning normally. It also inhibits the proliferation of tumor cells by binding to nucleophiles on DNA during replication. The anti-proliferative effects of 2,4-dichloro-6-methylpyridine are due to its ability to block a number of stages in the cell cycle.

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6-Bromopyridin-2-yl)methanol is a brominating reagent used in the synthesis of histidine and cyanuric acid. It has been shown to bind to metal ions via chelate ring, phenyl groups, and skeletal interactions. 6-Bromopyridin-2-yl)methanol forms ether linkages with carboxylic acid groups, making it an excellent solvent for ionic compounds. This compound also has optical properties that are dependent on the chloride counterion. 6-Bromopyridin-2-yl)methanol is bioinorganic and cryogenic, which makes it useful in hydrogen bonding probes.

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