Hétérocycles azotés (N)

3-(2-Pyridyl)-5,6-di(p-sulfophenyl)-1,2,4-triazinedisodiumsalt hydrate is a synthetic iron chelator that has been used in Chinese herbology as an acetate extract. The water vapor extracts of the plant have shown to have a strong effect on the polymerase chain reaction (PCR) and anion radical scavenging activity. 3-(2-Pyridyl)-5,6-di(p-sulfophenyl)-1,2,4-triazinedisodiumsalt hydrate is also effective in human serum and plasma mass spectrometry for the determination of iron binding. It has been shown to have a pH optimum range between 6.0 and 7.5, with maximum activity at pH 7.0. The monosodium salt form of 3-(2-Pyridyl)-5,6-di(p-sulfophen

Applications Reagent used to prepare biosynthetic polymer surfactants designed for shear-stable endothelialization. References Schaefer, A., et al.: J. Bacteriol., 178, 2897 (1996), Ruegsegger, M., et al.: J. Biomed. Mat. Res., 56, 159 (2001), Abdu-Allah, H., et al.: J. Med. Chem., 51, 6665 (2008), Georgiades, S., et al.: Bioorg. Med. Chem. Lett., 18, 3117 (2008),

2-Methoxy-3,5-dimethylpyrazine is a synthetic compound that can be used as a wastewater treatment agent. It has been shown to be effective in the removal of geosmin and other volatile organic compounds from wastewater. 2-Methoxy-3,5-dimethylpyrazine can be obtained by a chromatographic method or by a solid phase microextraction technique. The compound has not been found to have any health effects or toxic properties, but it does produce some structural isomers. Spectrometric data can be collected using this compound and the analytical methods are available for low detection levels and high sensitivity. The analytical methods use gas chromatography, mass spectrometry, or nuclear magnetic resonance spectroscopy.

(R)-4-Boc-2-methylpiperazine is a picolinamide dehydrogenase inhibitor that is used to treat type 2 diabetes. It has been shown to reduce blood glucose levels in animal models and human subjects with type 2 diabetes mellitus. The mechanism of action is thought to be via inhibition of the 11β-hydroxysteroid dehydrogenase, which increases insulin sensitivity. This drug also has good oral bioavailability, does not cause weight gain, and has an acceptable safety profile.

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