Sinalização Citoesquelética
Os inibidores de sinalização do citoesqueleto são compostos que interrompem as vias de sinalização que regulam o citoesqueleto, crucial para a forma celular, motilidade, divisão e transporte intracelular. Esses inibidores são usados para estudar a dinâmica das proteínas do citoesqueleto, como actina e tubulina, e seu papel em processos como migração celular, adesão e metástase do câncer. Os inibidores de sinalização do citoesqueleto são valiosos na pesquisa em biologia celular, câncer e neurobiologia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de sinalização do citoesqueleto de alta qualidade para apoiar sua pesquisa nessas áreas.
Produtos da "Sinalização Citoesquelética"
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Gly3-VC-PAB-MMAE
CAS:Gly3-VC-PAB-MMAE Compound consisting of the ADC linker Gly3-VC-PAB and the microtubule inhibitor MMAE, which can be used to synthesize ADC compounds.Fórmula:C64H103N13O15Cor e Forma:SolidPeso molecular:1294.58T-900607
CAS:T-900607 is a novel microtubule protein active agent that disrupts microtubule polymerization through a unique mechanism of action. t-900607 is cardiotoxic.Fórmula:C14H10F5N3O4SPureza:99%Cor e Forma:SolidPeso molecular:411.3HG-7-85-01
CAS:HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases.Fórmula:C31H31F3N6O2SPureza:98.08%Cor e Forma:SolidPeso molecular:608.68MKT-077
CAS:MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.Fórmula:C21H22ClN3OS2Pureza:98.2%Cor e Forma:SolidPeso molecular:432BIIB021
CAS:BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Fórmula:C14H15ClN6OPureza:98% - 99.82%Cor e Forma:SolidPeso molecular:318.76αvβ6-IN-2
αvβ6-IN-2 (compound 20) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 7.8. It shows potential for use in research on idiopathic pulmonary fibrosis.Fórmula:C25H30F3N3O3Cor e Forma:SolidPeso molecular:477.523-Phenyltoxoflavin
CAS:3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Fórmula:C13H11N5O2Pureza:98.84%Cor e Forma:SolidPeso molecular:269.26Ref: TM-T36123
1mg57,00€5mg120,00€10mg187,00€25mg338,00€50mg512,00€100mg753,00€200mg1.035,00€1mL*10mM (DMSO)133,00€Elarofiban TFA
CAS:Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.Fórmula:C26H34F6N4O8Pureza:100%Cor e Forma:SoildPeso molecular:644.56CH5138303
CAS:CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.Fórmula:C19H18ClN5O2SPureza:98%Cor e Forma:SolidPeso molecular:415.9Imatinib impurities3
CAS:Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.Fórmula:C24H20ClN5OPureza:97.05%Cor e Forma:SolidPeso molecular:429.9TRC051384 HCl
CAS:TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.Fórmula:C25H32ClN5O4Pureza:97.55%Cor e Forma:SolidPeso molecular:502.01AMP-PCP disodium
CAS:AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.Fórmula:C11H16N5Na2O12P3Pureza:100%Cor e Forma:SolidPeso molecular:549.17VER-82576
CAS:VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Fórmula:C21H23Cl2N5O2SPureza:98% - 99.16%Cor e Forma:SolidPeso molecular:480.41Bafetinib
CAS:Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.Fórmula:C30H31F3N8OPureza:94.16% - 99.68%Cor e Forma:SolidPeso molecular:576.62Ref: TM-T6311
1mg37,00€2mg52,00€5mg79,00€10mg103,00€25mg159,00€50mg188,00€100mg350,00€200mg455,00€1mL*10mM (DMSO)90,00€HSP90-IN-35
CAS:HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.Fórmula:C27H33N5O5Cor e Forma:SolidPeso molecular:507.58Pyrintegrin
CAS:Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.Fórmula:C23H25N5O3SPureza:97.81%Cor e Forma:SolidPeso molecular:451.54Ref: TM-T16695
1mg82,00€2mg96,00€5mg159,00€10mg226,00€25mg435,00€50mg648,00€100mg924,00€200mg1.225,00€1mL*10mM (DMSO)168,00€KX2-361
CAS:KX2-361 is a orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastomaFórmula:C24H24FN3O2Pureza:98.52% - 99.86%Cor e Forma:SolidPeso molecular:405.46Ref: TM-T9411
1mg81,00€5mg170,00€10mg235,00€25mg386,00€50mg543,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)182,00€Erbulozole
CAS:Erbulozole (R 55104) is a synthetic microtubule inhibitor with anti-invasive activity that induces Wernicke's encephalopathy-like neurotoxicity.Fórmula:C24H27N3O5SPureza:99.88%Cor e Forma:SolidPeso molecular:469.55Darovasertib
CAS:Darovasertib (LXS196) is a potent PKC inhibitor, orally active, with IC50 of 1.9 nM (PKCα), 0.4 nM (PKCθ), 3.1 μM (GSK3β).Fórmula:C22H23F3N8OPureza:98.72% - ≥95%Cor e Forma:SolidPeso molecular:472.47Ref: TM-T5600
1mg52,00€5mg136,00€10mg188,00€25mg350,00€50mg522,00€100mg750,00€200mg1.026,00€1mL*10mM (DMSO)149,00€CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Fórmula:C30H38ClN7O3Pureza:98.86% - 99.98%Cor e Forma:SolidPeso molecular:580.12
