TNF
TNF (Tumor Necrosis Factor) inhibitors are compounds that block the activity of TNF, a cytokine involved in inflammation and the regulation of apoptosis. TNF can induce apoptosis in some cell types while promoting survival and inflammation in others. Inhibiting TNF is crucial in the treatment of autoimmune diseases, chronic inflammatory conditions, and certain cancers. TNF inhibitors help to modulate the immune response and reduce tissue damage caused by excessive inflammation. At CymitQuimica, we provide a diverse range of high-quality TNF inhibitors to support your research in immunology, inflammation, and apoptosis.
Products of "TNF"
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Tilogotamab
CAS:Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).Purity:95%Color and Shape:LiquidUCB-9260
CAS:UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.Formula:C26H25N5OPurity:98.39% - 99.24%Color and Shape:SolidMolecular weight:423.51Trifolirhizin
CAS:Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Formula:C22H22O10Purity:98% - 99.67%Color and Shape:SolidMolecular weight:446.4HS-243
CAS:HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.Formula:C17H16N4O3Purity:97.34%Color and Shape:SolidMolecular weight:324.33Varlilumab
CAS:Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.Purity:SDS-PAGE:95% SEC-HPLC:98.65%Color and Shape:LiquidMolecular weight:146 kDaUCB-5307
CAS:UCB-5307 inhibits TNFR1, binds TNFα with 9 nM KD, shows slow kinetics (KD=6 nM), and penetrates hTNF/hTNFR1 complexes.Formula:C22H21N3OPurity:98.02%Color and Shape:SolidMolecular weight:343.42LASSBio-1135
CAS:LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.Formula:C18H14N4Purity:99.09%Color and Shape:SolidMolecular weight:286.33C 87
CAS:C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.Formula:C24H15ClN6O3SPurity:≥98%Color and Shape:SolidMolecular weight:502.93Cot inhibitor-2
CAS:Cot inhibitor-2: Potent, selective Tpl2/MAP3K8 blocker. IC50: 1.6 nM; hampers LPS-induced TNF-α, IC50: 0.3 μM. Orally active.Formula:C26H25Cl2FN8Purity:98.87%Color and Shape:SolidMolecular weight:539.43Ref: TM-T10866
1mg74.00€5mg165.00€10mg255.00€25mg537.00€50mg753.00€100mg1,074.00€200mg1,444.00€1mL*10mM (DMSO)190.00€Belimumab
CAS:Belimumab, a human IgG1λ monoclonal antibody, blocks BAFF, treating lupus and related fatigue.Purity:SDS-PAGE:98.4%;SEC-HPLC:98.4%Color and Shape:LiquidMolecular weight:144.07 kDaRuplizumab
CAS:PF-03732010 is a humanized antibody targeting P-calmodulin with antitumor and antimetastatic activity.Purity:95% - 95%Color and Shape:LiquidCot inhibitor-1
CAS:Cot inhibitor-1 selectively blocks Tpl2 kinase, reducing TNF-alpha in blood (IC50: 5.7 nM). It may treat arthritis, IBD, and certain cancers.Formula:C27H27Cl2FN8Purity:99.19%Color and Shape:SolidMolecular weight:553.46Ref: TM-T10865
1mg81.00€5mg169.00€10mg246.00€25mg445.00€50mg655.00€100mg998.00€200mg1,349.00€1mL*10mM (DMSO)197.00€Dapirolizumab
Dapirolizumab is an anti-CD40 monoclonal antibody used in research on systemic lupus erythematosus (SLE) and other autoimmune diseases.Color and Shape:LiquidMolecular weight:145.5 kDaBMS-561392
CAS:BMS-561392 (DPC333) is a tumor necrosis factor-α ( TNF-α) Invertase inhibitor.Formula:C27H32N4O4Purity:99.16%Color and Shape:SolidMolecular weight:476.57Siegeskaurolic acid
CAS:Siegeskaurolic acid reduces inflammation and pain by blocking iNOS and COX-2 in macrophages via NF-kappaB inactivation.Formula:C20H32O3Purity:98%Color and Shape:SolidMolecular weight:320.47Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurity:99.12%Color and Shape:SolidMolecular weight:512.46Neochlorogenic acid
CAS:Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.Formula:C16H18O9Purity:99.12% - 99.73%Color and Shape:White PowderMolecular weight:354.31Hispidol
CAS:Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colonFormula:C15H10O4Purity:97.86% - 98.45%Color and Shape:SolidMolecular weight:254.24Ref: TM-T4319
1mg44.00€2mg59.00€5mg87.00€10mg144.00€25mg212.00€50mg274.00€100mg432.00€200mg590.00€500mg1,008.00€1mL*10mM (DMSO)97.00€α-Humulene
CAS:α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatoryFormula:C15H24Purity:97.18% - 97.18%Color and Shape:LiquidMolecular weight:204.35RO7567132
RO7567132 is a bispecific antibody that binds and agonizes LTBR bivalently while binds and antagonizes FAP monovalently, inducing the formation of local TLS.Color and Shape:Odour Liquid
