Ferroptosis
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides and iron-dependent oxidative stress. Unlike apoptosis, ferroptosis is not driven by caspases but rather by the failure of cellular antioxidant defenses, leading to cell death. Ferroptosis inhibitors and inducers are critical for studying this unique cell death pathway, which is implicated in various diseases, including cancer, neurodegeneration, and ischemia-reperfusion injury. At CymitQuimica, we offer a wide range of high-quality ferroptosis modulators to support your research in cell death mechanisms, oxidative stress, and disease pathology.
Products of "Ferroptosis"
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UAMC-4821
UAMC-4821 is a ferroptosis inhibitor with an IC50 of 5.2 nM. It effectively scavenges free radicals, inhibits lipid peroxidation, and prevents ML162-induced ferroptosis, providing protective effects on HT-1080 cells. With favorable pharmacokinetic properties in mice, UAMC-4821 presents an oral bioavailability of 63% and demonstrates blood-brain barrier permeability.Formula:C15H19N3OColor and Shape:SolidMolecular weight:257.33Levobupivacaine hydrochloride
CAS:Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.Formula:C18H28N2O·HClPurity:99.74%Color and Shape:White Crystalline PowderMolecular weight:324.89Ferroptocide
CAS:Ferroptocide is a thioredoxin inhibitor that induces iron death in cancer cells and can be used in breast cancer research.Formula:C30H36ClN3O7Color and Shape:SolidMolecular weight:586.08Eugenol
CAS:Eugenol (Allylguaiacol) is a Standardized Chemical Allergen.Formula:C10H12O2Purity:99.72%Color and Shape:Colorless Or Pale Yellow Liquid Pungent Taste (Ntp 1992)Molecular weight:164.2NA-Ir
CAS:NA-Ir is a ferroptosis (Ferroptosis) inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to stimulate ferritin autophagy (). It also induces the production of reactive oxygen species (ROS) through photodynamic therapy (PDT), depletes glutathione (GSH), and downregulates glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and ferroptosis. NA-Ir exhibits enhanced anticancer activity under light exposure and selectively inhibits cancer cells with high H2S content.Formula:C49H36F6IrN8O4PColor and Shape:SolidMolecular weight:1138.04UAMC-3203
CAS:UAMC-3203 is a potent and selective Ferroptosis inhibitor (IC50: 12 nM).Formula:C25H37N5O2SPurity:100% - 98.81%Color and Shape:SolidMolecular weight:471.66L-BUTHIONINE-(S,R)-SULFOXIMINE
CAS:L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase that induces oxidative stress by depleting GSH.Formula:C8H18N2O3SPurity:97.07% - ≥98%Color and Shape:White Fine PowderMolecular weight:222.31Pseudolaric Acid B
CAS:Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.Formula:C23H28O8Purity:99.19% - 99.68%Color and Shape:SolidMolecular weight:432.46Ferroptosis-IN-16
Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.Formula:C26H23N5OColor and Shape:SolidMolecular weight:421.49Pifithrin-β hydrobromide
CAS:Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis.Formula:C16H17BrN2SPurity:99.24% - 99.74%Color and Shape:SolidMolecular weight:349.29U-73122
CAS:U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.Formula:C29H40N2O3Purity:97.50%Color and Shape:Solid Off-WhiteMolecular weight:464.64Necrostatin-1
CAS:Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity.Formula:C13H13N3OSPurity:100% - 99.81%Color and Shape:SolidMolecular weight:259.33Ref: TM-T1847
5mg35.00€10mg49.00€25mg82.00€50mg113.00€100mg170.00€200mg250.00€500mg419.00€1mL*10mM (DMSO)52.00€Pioglitazone hydrochloride
CAS:Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplasticFormula:C19H20N2O3S·HClPurity:100% - 99.66%Color and Shape:White Crystals Or Crystalline PowderMolecular weight:392.9Setanaxib
CAS:Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.Formula:C21H19ClN4O2Purity:93.468% - 99.66%Color and Shape:SolidMolecular weight:394.85Ref: TM-T6099
1g1,359.00€2mg40.00€5mg60.00€10mg96.00€25mg177.00€50mg319.00€100mg507.00€500mg1,093.00€1mL*10mM (DMSO)66.00€Bardoxolone Methyl
CAS:Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-Formula:C32H43NO4Purity:97.81% - 99.09%Color and Shape:SolidMolecular weight:505.69Ref: TM-T6165
10mg47.00€25mg65.00€50mg88.00€100mg119.00€200mg187.00€500mg424.00€1mL*10mM (DMSO)50.00€Atorvastatin hemicalcium salt
CAS:Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an orally HMG-CoA reductase inhibitor that lowers cholesterol. Cost-effective and quality-assured.Formula:C33H34FN2O5CaPurity:99.27% - 99.89%Color and Shape:White Crystalline PowderMolecular weight:577.67CQ-ER
CQ-ER is a Coumarin-quinazolinone-based photosensitizer targeting the endoplasmic reticulum (ER). It induces ferroptosis, thereby enhancing photodynamic therapy (PDT).Formula:C33H33N7O6SColor and Shape:SolidMolecular weight:655.72Ferroptosis-IN-6
CAS:Ferroptosis-IN-6 is an efficient ferroptosis inhibitor, protecting cells from cell death induced by ferroptosis inducers, and inhibiting STY-BODIPY oxidation.Formula:C15H17NOPurity:99.84%Color and Shape:SolidMolecular weight:227.3Ref: TM-T86417
1mg59.00€5mg127.00€10mg188.00€25mg395.00€50mg635.00€100mg1,017.00€200mg1,359.00€1mL*10mM (DMSO)139.00€(E)-Ferulic acid
CAS:(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression ofFormula:C10H10O4Purity:99.63%Color and Shape:SolidMolecular weight:194.186-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
CAS:Formula:C14H18O4Purity:98%Color and Shape:SolidMolecular weight:250.2903
