Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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JBJ-02-112-05
CAS:JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].Formula:C27H20N4O2SPurity:98%Color and Shape:SolidMolecular weight:464.54GSK2801
CAS:GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.Formula:C20H21NO4SPurity:97.78% - 99.5%Color and Shape:SolidMolecular weight:371.45TP-064
CAS:TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.Formula:C28H34N4O2Purity:97.85%Color and Shape:SolidMolecular weight:458.6Ref: TM-T28996
1mg38.00€2mg49.00€5mg79.00€10mg119.00€25mg245.00€50mg487.00€100mg710.00€1mL*10mM (DMSO)80.00€PU139
CAS:PU139 is a novel inhibitor of histone acetyltransferase (HAT).Formula:C12H7FN2OSPurity:97.61%Color and Shape:SolidMolecular weight:246.26SMI-16a
CAS:SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Formula:C13H13NO3SPurity:99.99%Color and Shape:SolidMolecular weight:263.31Ref: TM-T3989
1mg35.00€2mg48.00€5mg70.00€10mg87.00€25mg160.00€50mg235.00€100mg354.00€1mL*10mM (DMSO)92.00€Neogrifolin
CAS:Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OSFormula:C22H32O2Purity:98%Color and Shape:SolidMolecular weight:328.49BET-IN-27
CAS:BET-IN-27 (compound 6C) is an orally active BET inhibitor with IC50 values of 3.3 nM (BRD4-BD2), 3.4 nM (BRD4-BD1), 4.1 nM (BRD2-BD1), 20.4 nM (BRD3-BD1), and 42.0 nM (BRDT-BD1). It also exhibits antiproliferative activity.Formula:C21H23N5O3SColor and Shape:SolidMolecular weight:425.5JQEZ5
CAS:JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).Formula:C30H38N8O2Purity:98.14% - ≥98%Color and Shape:SolidMolecular weight:542.68GDC-9918
CAS:GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.Formula:C20H18F2N6O5SColor and Shape:SolidMolecular weight:492.46JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Color and Shape:Odour SolidOICR-9429
CAS:OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.Formula:C29H32F3N5O3Purity:99.13% - 99.93%Color and Shape:SolidMolecular weight:555.59Ref: TM-T6916
1mg37.00€2mg52.00€5mg74.00€10mg111.00€25mg187.00€50mg311.00€100mg502.00€1mL*10mM (DMSO)97.00€YDR1
CAS:YDR1 is an effective PROTAC degrader of SMARCA2, featuring a DC50 value of 7.7 nM.Formula:C44H49FN10O5Color and Shape:SolidMolecular weight:816.92AMI-1 free acid
CAS:AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.Formula:C21H16N2O9S2Purity:97.8%Color and Shape:SolidMolecular weight:504.49HLCL-61
CAS:HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).Formula:C23H24N2OColor and Shape:SolidMolecular weight:344.45(S,R,S)-AHPC-Me-amide-C9-acid
CAS:(S,R,S)-AHPC-Me-amide-C9-acid is an E3 ligase ligand-linker conjugate utilized in synthesizing PROTACSMARCA2 degrader-31.Formula:C34H50N4O6SColor and Shape:SolidMolecular weight:642.85FM-381
CAS:FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.Formula:C24H24N6O2Purity:98.44%Color and Shape:SolidMolecular weight:428.49MAT2A-IN-10
CAS:MAT2A-IN-10 (Compound 28), an orally active inhibitor of MAT2A, exhibits an IC50 of 26 nM and is utilized in cancer research [1].Formula:C27H24F2N6O4Purity:98%Color and Shape:SolidMolecular weight:534.51SETD7-IN-1
SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitoryPurity:98%Color and Shape:Odour SolidGSK-J1
CAS:GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively.Formula:C22H23N5O2Purity:99.23% - 99.67%Color and Shape:SolidMolecular weight:389.45MOZ-IN-2
CAS:MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).Formula:C17H13FN4O3SPurity:99.17%Color and Shape:SolidMolecular weight:372.37Ref: TM-T12098
2mg37.00€5mg60.00€10mg96.00€25mg188.00€50mg283.00€100mg432.00€500mg938.00€1mL*10mM (DMSO)66.00€
