Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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AMI-408
CAS:AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.Formula:C20H13Cl2N6NaO5SColor and Shape:SolidMolecular weight:543.32MS7972
CAS:MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μMFormula:C14H13NO2Purity:99.78%Color and Shape:SolidMolecular weight:227.26Ref: TM-T8774
1mg57.00€5mg111.00€10mg183.00€25mg311.00€50mg449.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)123.00€Barasertib-HQPA
CAS:Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.Formula:C26H30FN7O3Purity:98.43% - 99.29%Color and Shape:SolidMolecular weight:507.56AAPK-25
CAS:AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formula:C21H13Cl2N3O2SPurity:97.79%Color and Shape:SolidMolecular weight:442.32Ref: TM-T10215
1mg95.00€5mg202.00€10mg303.00€25mg550.00€50mg825.00€100mg1,198.00€1mL*10mM (DMSO)233.00€PROTAC BRD4 Degrader-2
CAS:PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).Formula:C40H39N9O7Purity:98%Color and Shape:SolidMolecular weight:757.79KDM1A-IN-29
CAS:KDM1A-IN-29 is a histone demethylase inhibitor.Formula:C16H16ClN3O4SColor and Shape:SoildMolecular weight:381.83Larsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Formula:C27H49NO5SPurity:100% - 100%Color and Shape:SoildMolecular weight:499.75Hispidulin
CAS:Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).Formula:C16H12O6Purity:97.54% - 98.53%Color and Shape:SolidMolecular weight:300.26BI-9564
CAS:BI-9564, a specific cell-permeable BRD9 BD inhibitor. The Kd for BRD9 is 5.9 nM, and IC50 for BET family is > 100 μM.Formula:C20H23N3O3Purity:98.77%Color and Shape:SolidMolecular weight:353.41PF-9366
CAS:PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor (IC50: 420 nM; Kd: 170 nM).Formula:C20H19ClN4Purity:100% - 98.99%Color and Shape:SolidMolecular weight:350.84HDAC-IN-87
CAS:HDAC-IN-87 (Compound XII6) is a non-selective HDAC inhibitor with pIC50 values of 6.9 for HDAC4 and 5.8 for HDAC6. It exhibits fungicidal activity against P. sorghi and P. pachyrhizi. The acute oral LD50 in both male and female rats is greater than 500 mg/kg.Formula:C13H7F5N4O2SColor and Shape:SolidMolecular weight:378.277Pim1/AKK1-IN-1
CAS:Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.Formula:C20H13N5OPurity:97.84% - 98.69%Color and Shape:SolidMolecular weight:339.35Ref: TM-T5093
1mg89.00€2mg131.00€5mg183.00€10mg278.00€25mg490.00€50mg710.00€100mg998.00€1mL*10mM (DMSO)202.00€Milpecitinib
CAS:Milpecitinib (Compound 21a) is a potent and selective Janus tyrosine kinase (JAK) inhibitor with anti-inflammatory properties. It shows promise for research in cancer and inflammatory diseases.Formula:C20H20N4O2SColor and Shape:SolidMolecular weight:380.463BRD4-BD1-IN-2
CAS:BRD4-BD1-IN-2: Potent, selective BRD4-BD1 inhibitor, IC50=2.51µM; 20x less active on BD2; for cardiovascular/cancer research.Formula:C20H15Br3N4O2Purity:99.47%Color and Shape:SolidMolecular weight:583.07ZEN-3694
CAS:ZEN-3694 (ZEN 3694) is a bromo-structural domain extra-terminal inhibitor (BETi) with activity in androgen signaling inhibitor (ASI) resistance models and canFormula:C19H19N5OPurity:98.88% - 99.48%Color and Shape:SolidMolecular weight:333.39PF-CBP1
CAS:PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).Formula:C29H36N4O3Purity:99.45%Color and Shape:SolidMolecular weight:488.62Ref: TM-T3973
2mg34.00€5mg46.00€10mg72.00€25mg128.00€50mg224.00€100mg331.00€200mg465.00€1mL*10mM (DMSO)46.00€PLX51107
CAS:PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).Formula:C26H22N4O3Purity:99.75%Color and Shape:SolidMolecular weight:438.48Ref: TM-TQ0253
1mg56.00€2mg81.00€5mg119.00€10mg188.00€25mg329.00€50mg490.00€100mg710.00€1mL*10mM (DMSO)131.00€UNC6934
CAS:UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.Formula:C24H21N5O4Purity:99.81%Color and Shape:SolidMolecular weight:443.45Ref: TM-T9584
1mg86.00€2mg111.00€5mg180.00€10mg283.00€25mg455.00€50mg645.00€100mg882.00€500mg1,758.00€1mL*10mM (DMSO)188.00€Aurora kinase inhibitor-3
CAS:Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formula:C21H18F3N5OPurity:98.91%Color and Shape:SolidMolecular weight:413.4Ref: TM-T5524
1mg78.00€2mg97.00€5mg188.00€10mg298.00€25mg500.00€50mg710.00€100mg938.00€200mg1,311.00€1mL*10mM (DMSO)215.00€EP300/CBP ligand 2
EP300/CBP ligand 2 (compound S19) serves as a specific ligand for the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). It plays a critical role in PROTAC technology by acting as a target protein ligand. By linking to an E3 ubiquitin ligase ligand via the PROTAC Linker, it facilitates the synthesis of PROTAC molecules capable of targeted protein degradation. For instance, when EP300/CBP ligand 2 is connected to the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc, it results in the formation of the PROTAC molecule dCE-2.Formula:C20H18N6OColor and Shape:SolidMolecular weight:358.4
