Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
Sort by
GNE-064
CAS:GNE-064: Oral SMARCA4/2, PBRM1 inhibitor; IC50 (SMARCA4)=0.035µM, EC50 (SMARCA2)=0.1µM; High solubility; Research probe.Formula:C17H21N5O2Purity:99.81%Color and Shape:SoildMolecular weight:327.38PROTAC HDAC6 degrader 4
PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]Formula:C39H42FN9O7Color and Shape:SolidMolecular weight:767.81PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Formula:C22H26N4O3Purity:98.82%Color and Shape:SolidMolecular weight:394.47PARP1-IN-30
CAS:PARP1-IN-30 is a specific and effective PARP1 inhibitor with cytotoxic properties. It precisely inhibits PARP1 in tumor cells lacking breast cancer 1 protein (BRCA1) or BRCA2. PARP1-IN-30 holds potential for use in cancer research.Formula:C14H12ClNO4SColor and Shape:SolidMolecular weight:325.77(R)-9b
CAS:(R)-9b is an effective inhibitor of the ACK1 tyrosine kinase (IC50=56 nM) and exhibits anticancer activity. It selectively targets ACK1 but also inhibits kinases in the JAK family, specifically JAK2 and Tyk2. (R)-9b is used in research related to hormone-regulated cancers, such as prostate cancer and breast cancer.Formula:C20H27ClN6OColor and Shape:SolidMolecular weight:402.92BGP-15
CAS:BGP-15 (BGP-15 2HCl) is a PARP inhibitor with protecting effect after ischemia-reperfusion injury.Formula:C14H24Cl2N4O2Purity:99.02% - 99.89%Color and Shape:SolidMolecular weight:351.27L-2-Hydroxyglutaric acid
CAS:L-2-Hydroxyglutaric acid (L-2-HG) is a substrate of L2HGDH and inhibits histone demethylases.Formula:C5H8O5Purity:98%Color and Shape:SolidMolecular weight:148.11(S)-GNE-987
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).Formula:C56H67F2N9O8S2Purity:98%Color and Shape:SolidMolecular weight:1096.31Tz-Thalidomide
CAS:Tz-Thalidomide is a tetrazine-modified Thalidomide (E3 ligase ligand) with some affinity for BRD4.Formula:C29H29N7O6Purity:98.34%Color and Shape:SolidMolecular weight:571.58JNJ-7706621
CAS:JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.Formula:C15H12F2N6O3SPurity:99.1% - 99.66%Color and Shape:SolidMolecular weight:394.36Ref: TM-T6126
1mg50.00€2mg66.00€5mg105.00€10mg180.00€25mg284.00€50mg520.00€100mg728.00€500mg1,473.00€1mL*10mM (DMSO)88.00€SW2_110A
CAS:SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.Formula:C42H60N6O7Purity:98%Color and Shape:SolidMolecular weight:760.96SD-1029
CAS:SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.Formula:C25H32Br2Cl2N2O3Color and Shape:SolidMolecular weight:639.25Y06137
CAS:Y06137, selective BET inhibitor, Kd 81 nM for BRD4(1), researched for castration-resistant prostate cancer treatment.Formula:C27H32N4O2Purity:97.27%Color and Shape:SolidMolecular weight:444.57K00135
CAS:K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.Formula:C18H18N4OPurity:97.88%Color and Shape:SolidMolecular weight:306.36Ref: TM-T27704
1mg185.00€2mg279.00€5mg426.00€10mg627.00€25mg938.00€50mg1,320.00€100mg1,786.00€500mg3,591.00€1mL*10mM (DMSO)415.00€MS023
CAS:MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,Formula:C17H25N3OPurity:98.31% - 99.28%Color and Shape:SolidMolecular weight:287.4Ref: TM-T6900
1mg39.00€2mg51.00€5mg88.00€10mg119.00€25mg243.00€50mg378.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)84.00€Abrocitinib
CAS:Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formula:C14H21N5O2SPurity:99.09% - 99.91%Color and Shape:SolidMolecular weight:323.41Ref: TM-TQ0037
1mg85.00€2mg107.00€5mg167.00€10mg284.00€25mg467.00€50mg692.00€100mg938.00€1mL*10mM (DMSO)188.00€GSK-5959
CAS:GSK-5959 is a selective BRPF1 inhibitor with IC50 ~80 nM, 100-fold more specific than 35 other bromodomains.Formula:C22H26N4O3Purity:98.35% - 98.65%Color and Shape:SolidMolecular weight:394.47SW2_110A acetate
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).Formula:C44H64N6O9Purity:98%Color and Shape:SoildMolecular weight:821.01Cedazuridine
CAS:Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.Formula:C9H14F2N2O5Purity:99.46%Color and Shape:SolidMolecular weight:268.21KDM5-C49 HCl
KDM5-C49 HCl (KDOAM-20 hydrochloride) is a potent and selective inhibitor of KDM5 demethylase.Formula:C15H25ClN4O3Purity:98.59%Color and Shape:SolidMolecular weight:344.84Ref: TM-T27723L
1mg185.00€5mg409.00€10mg605.00€25mg938.00€50mg1,293.00€100mg1,738.00€500mg3,496.00€1mL*10mM (DMSO)420.00€
