HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Products of "HIF/HIF Prolyl-Hydroxylase"
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TC-S 7009
CAS:TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene expression.Formula:C12H6ClFN4O3Purity:100% - 99.71%Color and Shape:SolidMolecular weight:308.65PHD-IN-2
CAS:PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 ofFormula:C26H27N7O4Purity:98%Color and Shape:SolidMolecular weight:501.54Tilorone dihydrochloride
CAS:Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.Formula:C25H36Cl2N2O3Purity:98% - 99.86%Color and Shape:Orange Yellow Crystal PowderMolecular weight:483.47SYP-5
CAS:SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.Formula:C18H16O3SPurity:98.31%Color and Shape:SolidMolecular weight:312.38Enarodustat
CAS:Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.Formula:C17H16N4O4Purity:99.14% - 99.61%Color and Shape:SolidMolecular weight:340.33Ref: TM-T15219
1mg39.00€2mg50.00€5mg79.00€10mg115.00€25mg188.00€50mg311.00€100mg462.00€1mL*10mM (DMSO)90.00€HIF-2α-IN-9
CAS:HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes withinFormula:C12H13F5O4S2Purity:98%Color and Shape:SolidMolecular weight:380.35GN44028
CAS:GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.Formula:C18H15N3O2Purity:98.20%Color and Shape:SolidMolecular weight:305.33Ref: TM-T15396
1mg70.00€5mg135.00€10mg188.00€25mg325.00€50mg465.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)149.00€2,4-DPD
CAS:2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)Formula:C11H13NO4Purity:99.74%Color and Shape:Yellow Solid CrystallineMolecular weight:223.23Ethyl 3,4-dihydroxybenzoate
CAS:Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Formula:C9H10O4Purity:99.88%Color and Shape:White Crystal Or PowderMolecular weight:182.17ZK-261991
CAS:ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).Formula:C24H25N7O2Purity:98%Color and Shape:SolidMolecular weight:443.5Desidustat
CAS:Desidustat is an inhibitor of HIF hydroxylase.Formula:C16H16N2O6Purity:98%Color and Shape:SolidMolecular weight:332.31Ref: TM-T5176
1mg35.00€2mg52.00€5mg94.00€10mg167.00€25mg300.00€50mg516.00€100mg732.00€1ml*10 (DMSO)112.00€Belzutifan
CAS:"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."Formula:C17H12F3NO4SPurity:99.34% - 99.41%Color and Shape:SolidMolecular weight:383.34Ref: TM-T16679
1mg70.00€5mg153.00€10mg216.00€25mg411.00€50mg660.00€100mg938.00€200mg1,264.00€1mL*10mM (DMSO)166.00€DDO-3055
CAS:DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.Formula:C17H13ClN2O5Color and Shape:SolidMolecular weight:360.749HIF-1 inhibitor-4
CAS:HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.Formula:C18H19IN2O2Purity:99.17%Color and Shape:SolidMolecular weight:422.26Ref: TM-T67767
1mg48.00€5mg96.00€10mg157.00€25mg281.00€50mg454.00€100mg702.00€200mg938.00€1mL*10mM (DMSO)116.00€IDF-11774
CAS:IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).Formula:C23H32N2O2Purity:98.05%Color and Shape:SolidMolecular weight:368.51Citric acid trilithium salt tetrahydrate
CAS:Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy ofFormula:C6H13Li3O11Purity:≥95%Color and Shape:White Crystalline PowderMolecular weight:281.98IOX2
CAS:IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.Formula:C19H16N2O5Purity:98% - 99.59%Color and Shape:SolidMolecular weight:352.34Fenbendazole
CAS:Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.Formula:C15H13N3O2SPurity:99.74%Color and Shape:White To Yellowish PowderMolecular weight:299.35Izilendustat
CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Formula:C22H28ClN3O4Purity:99.95%Color and Shape:SolidMolecular weight:433.93Ref: TM-T64336
5mg46.00€10mg64.00€25mg109.00€50mg170.00€100mg273.00€200mg399.00€1mL*10mM (DMSO)49.00€HIV-IN-7
Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.Formula:C32H61N3O10P2Purity:98%Color and Shape:SolidMolecular weight:709.79
