GluR
Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.
Products of "GluR"
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ADX88178
CAS:ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.Formula:C12H12N6SPurity:99.55%Color and Shape:SolidMolecular weight:272.33Ref: TM-T4500
2mg38.00€5mg58.00€10mg96.00€25mg156.00€50mg243.00€100mg354.00€200mg505.00€1mL*10mM (DMSO)60.00€LY392098
CAS:LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.Formula:C18H22FNO2SPurity:99.85%Color and Shape:SolidMolecular weight:335.44Ref: TM-T27951
1mg42.00€5mg87.00€10mg140.00€25mg226.00€50mg324.00€100mg437.00€200mg605.00€1mL*10mM (DMSO)92.00€NS 1209
CAS:NS 1209 (SPD 502) is a AMPA receptor antagonist.Formula:C24H27N4NaO7SPurity:98%Color and Shape:SolidMolecular weight:538.55PHCCC
CAS:PHCCC is a Group I mGluR antagonist and enhances mGluR4 function; also blocks mGluR2/8.Formula:C17H14N2O3Purity:99.31%Color and Shape:SolidMolecular weight:294.3(S)-3,4-DCPG HCl
(S)-3,4-DCPG HCl is a selective mGluR8a agonist, impacting AV12-664 cells with an EC50 of 31 nM.Formula:C10H10ClNO6Purity:99.06% - 99.90%Color and Shape:SoildMolecular weight:275.64Ref: TM-T23288L
1mg183.00€5mg462.00€10mg660.00€25mg1,035.00€50mg1,415.00€100mg1,872.00€500mg3,763.00€1mL*10mM (DMSO)415.00€Dasolampanel
CAS:Dasolampanel (NGX-426) is an ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders.Formula:C17H20ClN5O3Purity:99%Color and Shape:SolidMolecular weight:377.83VU0360172
CAS:VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).Formula:C18H15FN2OPurity:99.65%Color and Shape:SolidMolecular weight:294.32Ref: TM-T29126
1mg57.00€5mg120.00€10mg187.00€25mg376.00€50mg588.00€100mg833.00€1mL*10mM (DMSO)115.00€XAP044
CAS:XAP044 blocks mGlu7, inhibiting long-term potentiation in mouse brain with a half-maximal effect at 88nm.Formula:C15H9IO4Purity:97.41%Color and Shape:SolidMolecular weight:380.13Ref: TM-T21995
1mg62.00€2mg87.00€5mg113.00€10mg207.00€25mg369.00€50mg557.00€100mg797.00€1mL*10mM (DMSO)155.00€DHPG
CAS:DHPG is a potent Group I mGluR agonist; doesn't affect Group II/III; linked to phospholipase D.Formula:C8H9NO4Purity:99.55%Color and Shape:SolidMolecular weight:183.16VU0361737
CAS:VU0361737 (ML-128) is a mGlu4 PAM; EC50 is 240 nM (human) and 110 nM (rat), weak at mGlu5/8, inactive at mGlu1/2/3/6/7, CNS-penetrant.Formula:C13H11ClN2O2Purity:99.09% - 99.86%Color and Shape:SolidMolecular weight:262.69Philanthotoxin 74 dihydrochloride
CAS:Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.Formula:C24H44Cl2N4O3Purity:98.6%Color and Shape:SolidMolecular weight:507.54CNQX
CAS:CNQX (FG9065) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)Formula:C9H4N4O4Purity:99.70%Color and Shape:Pale Yellow SolidMolecular weight:232.15Ro 67-7476
CAS:Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.Formula:C17H18FNO2SPurity:99.48%Color and Shape:SolidMolecular weight:319.39Ref: TM-T3478
1mg35.00€2mg50.00€5mg93.00€10mg131.00€25mg258.00€50mg465.00€100mg680.00€1mL*10mM (DMSO)82.00€JNJ-46281222
CAS:JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.Formula:C23H25F3N4Color and Shape:SolidMolecular weight:414.47Ref: TM-T8862
1mg37.00€5mg80.00€10mg116.00€25mg259.00€50mg383.00€100mg545.00€200mg740.00€1mL*10mM (DMSO)93.00€IDRA-21
CAS:IDRA-21 is a positive AMPA receptor modulator.Formula:C8H9ClN2O2SPurity:99.73%Color and Shape:SolidMolecular weight:232.69DMeOB
CAS:DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and is used in the study of neurological disorders.Formula:C16H16N2O2Purity:98.34%Color and Shape:SolidMolecular weight:268.31Ref: TM-T22736
1mg35.00€5mg70.00€10mg104.00€25mg202.00€50mg311.00€100mg472.00€500mg1,017.00€1mL*10mM (DMSO)85.00€JNJ-55511118
CAS:JNJ-55511118 is a TARP γ8 allosteric modulator with anticonvulsant activity, which can be used in research on chronic operant alcohol self-administration.Formula:C14H8ClF3N2O2Color and Shape:SolidMolecular weight:328.67Pomaglumetad methionil hydrochloride
CAS:LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.Formula:C12H19ClN2O7S2Purity:99.01%Color and Shape:SolidMolecular weight:402.87Basimglurant
CAS:Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).Formula:C18H13ClFN3Purity:98.35%Color and Shape:SolidMolecular weight:325.77Ref: TM-T12717
1mg78.00€5mg169.00€10mg246.00€25mg406.00€50mg562.00€100mg702.00€200mg949.00€1mL*10mM (DMSO)178.00€
