Sirtuin
Las sirtuinas son una familia de desacetilasas dependientes de NAD+ que desempeñan un papel crucial en la regulación de procesos celulares como la reparación del ADN, el envejecimiento, el metabolismo y la resistencia al estrés. Las sirtuinas influyen en la reparación del ADN desacetilando proteínas involucradas en las vías de reparación, modulando así su actividad. Los inhibidores y activadores de sirtuinas son herramientas valiosas en la investigación sobre el envejecimiento, el cáncer y las enfermedades metabólicas, donde la regulación de la reparación del ADN y la longevidad celular es de interés. En CymitQuimica, ofrecemos una gama de moduladores de sirtuinas de alta calidad para apoyar su investigación en reparación del ADN, envejecimiento celular y regulación metabólica.
Productos de "Sirtuin"
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SirReal2
CAS:SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.Fórmula:C22H20N4OS2Pureza:98.96% - 99.75%Forma y color:SolidPeso molecular:420.55Ref: TM-T6984
1mg39,00€2mg50,00€5mg79,00€10mg107,00€25mg197,00€50mg311,00€100mg505,00€1mL*10mM (DMSO)90,00€Splitomicin
CAS:Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in aFórmula:C13H10O2Pureza:98.64% - 99.11%Forma y color:SolidPeso molecular:198.22Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Fórmula:C13H13ClN2OPureza:98.53% - 99.79%Forma y color:SolidPeso molecular:248.71Ref: TM-T6111
5mg50,00€10mg57,00€25mg93,00€50mg140,00€100mg235,00€200mg349,00€500mg565,00€1mL*10mM (DMSO)52,00€WAY-354574
CAS:WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].Fórmula:C20H23ClN2O3SPureza:98%Forma y color:SolidPeso molecular:406.93YM-08
CAS:YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Fórmula:C19H17N3OS2Pureza:98%Forma y color:SolidPeso molecular:367.49Ophiopogonin D'
CAS:Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.Fórmula:C44H70O16Pureza:99.13%Forma y color:SolidPeso molecular:855.02MIND4-19
CAS:MIND4-19 is an inhibitor of SIRT2 with antitumor activity.Fórmula:C22H19N3OSPureza:99.9%Forma y color:SolidPeso molecular:373.47SRT3657
CAS:SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.Fórmula:C40H54N8O6SPureza:98%Forma y color:SolidPeso molecular:774.97YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFórmula:C19H21BO7Pureza:99.47%Forma y color:SolidPeso molecular:372.18Ref: TM-T9320
2mg40,00€5mg60,00€10mg87,00€25mg180,00€50mg305,00€100mg535,00€200mg690,00€500mg1.074,00€1mL*10mM (DMSO)66,00€SIRT5 inhibitor 3
CAS:SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Fórmula:C22H12FN3O4Pureza:98%Forma y color:SolidPeso molecular:401.35SIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Forma y color:Odour SolidJGB1741
CAS:JGB1741, a SIRT1 inhibitor (IC50=15µM), modulates apoptosis markers and p53 acetylation in breast cancer research.Fórmula:C27H24N2O2SPureza:97.24%Forma y color:SolidPeso molecular:440.56SIRT5 inhibitor 6
CAS:SIRT5 Inhibitor 6 is a potent, selective, and substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 3.0 μM, and demonstrates therapeutic potential forFórmula:C21H28N6O4SPureza:99.82%Forma y color:SolidPeso molecular:460.55SIRT1-IN-1
CAS:SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Fórmula:C14H16N2OPureza:99.31%Forma y color:SolidPeso molecular:228.29Ref: TM-T9648
1mg96,00€5mg202,00€10mg311,00€25mg533,00€50mg747,00€100mg1.017,00€200mg1.359,00€1mL*10mM (DMSO)207,00€Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Fórmula:C19H15N3O2SPureza:99.47%Forma y color:SolidPeso molecular:349.41Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Fórmula:C21H16N2O2SPureza:98.47% - 99.83%Forma y color:SolidPeso molecular:360.43Ref: TM-T4019
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg522,00€500mg1.130,00€1mL*10mM (DMSO)66,00€Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Fórmula:C25H34N4O2SPureza:100% - 97.71%Forma y color:SolidPeso molecular:454.63Ref: TM-T1818
1mg43,00€2mg56,00€5mg77,00€10mg87,00€25mg157,00€50mg230,00€100mg393,00€500mg930,00€1mL*10mM (DMSO)79,00€Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Fórmula:C51H34N6Na6O23S6Pureza:97.47% - 99.97%Forma y color:WhitePeso molecular:1429.15SIRT1 activator 1
SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.Pureza:98%Forma y color:Odour SolidSRT1720 hydrochloride
CAS:SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).Fórmula:C25H24ClN7OSPureza:98% - 99.93%Forma y color:SolidPeso molecular:506.22Ref: TM-T2412
1mg69,00€2mg89,00€5mg139,00€10mg250,00€25mg394,00€50mg562,00€100mg800,00€200mg1.103,00€500mg1.634,00€1mL*10mM (DMSO)221,00€
