HIF / HIF Prolilhidroxilasa
El Factor Inducible por Hipoxia (HIF) es un factor de transcripción que desempeña un papel crucial en las respuestas celulares a bajos niveles de oxígeno (hipoxia). La actividad del HIF está regulada estrictamente por las prolil-hidroxilasas de HIF, que dirigen al HIF para su degradación en condiciones normóxicas. Los inhibidores de la prolil-hidroxilasa de HIF pueden estabilizar el HIF, promoviendo la expresión de genes involucrados en la angiogénesis, la eritropoyesis y el metabolismo. Estos inhibidores son de gran interés en el tratamiento de afecciones como la anemia, las enfermedades isquémicas y el cáncer. En CymitQuimica, ofrecemos inhibidores de HIF/prolil-hidroxilasa HIF para apoyar su investigación en biología de la hipoxia, terapia del cáncer y regulación metabólica.
Productos de "HIF / HIF Prolilhidroxilasa"
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TC-S 7009
CAS:TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene expression.Fórmula:C12H6ClFN4O3Pureza:100% - 99.71%Forma y color:SolidPeso molecular:308.65PHD-IN-2
CAS:PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 ofFórmula:C26H27N7O4Pureza:98%Forma y color:SolidPeso molecular:501.54Tilorone dihydrochloride
CAS:Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.Fórmula:C25H36Cl2N2O3Pureza:98% - 99.86%Forma y color:Orange Yellow Crystal PowderPeso molecular:483.47SYP-5
CAS:SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.Fórmula:C18H16O3SPureza:98.31%Forma y color:SolidPeso molecular:312.38Enarodustat
CAS:Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.Fórmula:C17H16N4O4Pureza:99.14% - 99.61%Forma y color:SolidPeso molecular:340.33Ref: TM-T15219
1mg39,00€2mg50,00€5mg79,00€10mg115,00€25mg188,00€50mg311,00€100mg462,00€1mL*10mM (DMSO)90,00€HIF-2α-IN-9
CAS:HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes withinFórmula:C12H13F5O4S2Pureza:98%Forma y color:SolidPeso molecular:380.35GN44028
CAS:GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.Fórmula:C18H15N3O2Pureza:98.20%Forma y color:SolidPeso molecular:305.33Ref: TM-T15396
1mg70,00€5mg135,00€10mg188,00€25mg325,00€50mg465,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)149,00€2,4-DPD
CAS:2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)Fórmula:C11H13NO4Pureza:99.74%Forma y color:Yellow Solid CrystallinePeso molecular:223.23Ethyl 3,4-dihydroxybenzoate
CAS:Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Fórmula:C9H10O4Pureza:99.88%Forma y color:White Crystal Or PowderPeso molecular:182.17ZK-261991
CAS:ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).Fórmula:C24H25N7O2Pureza:98%Forma y color:SolidPeso molecular:443.5Desidustat
CAS:Desidustat is an inhibitor of HIF hydroxylase.Fórmula:C16H16N2O6Pureza:98%Forma y color:SolidPeso molecular:332.31Ref: TM-T5176
1mg35,00€2mg52,00€5mg94,00€10mg167,00€25mg300,00€50mg516,00€100mg732,00€1ml*10 (DMSO)112,00€Belzutifan
CAS:"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."Fórmula:C17H12F3NO4SPureza:99.34% - 99.41%Forma y color:SolidPeso molecular:383.34Ref: TM-T16679
1mg70,00€5mg153,00€10mg216,00€25mg411,00€50mg660,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)166,00€DDO-3055
CAS:DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.Fórmula:C17H13ClN2O5Forma y color:SolidPeso molecular:360.749HIF-1 inhibitor-4
CAS:HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.Fórmula:C18H19IN2O2Pureza:99.17%Forma y color:SolidPeso molecular:422.26Ref: TM-T67767
1mg48,00€5mg96,00€10mg157,00€25mg281,00€50mg454,00€100mg702,00€200mg938,00€1mL*10mM (DMSO)116,00€IDF-11774
CAS:IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).Fórmula:C23H32N2O2Pureza:98.05%Forma y color:SolidPeso molecular:368.51Citric acid trilithium salt tetrahydrate
CAS:Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy ofFórmula:C6H13Li3O11Pureza:≥95%Forma y color:White Crystalline PowderPeso molecular:281.98IOX2
CAS:IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.Fórmula:C19H16N2O5Pureza:98% - 99.59%Forma y color:SolidPeso molecular:352.34Fenbendazole
CAS:Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.Fórmula:C15H13N3O2SPureza:99.74%Forma y color:White To Yellowish PowderPeso molecular:299.35Izilendustat
CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Fórmula:C22H28ClN3O4Pureza:99.95%Forma y color:SolidPeso molecular:433.93Ref: TM-T64336
5mg46,00€10mg64,00€25mg109,00€50mg170,00€100mg273,00€200mg399,00€1mL*10mM (DMSO)49,00€HIV-IN-7
Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.Fórmula:C32H61N3O10P2Pureza:98%Forma y color:SolidPeso molecular:709.79
