HIF / HIF Prolilhidroxilasa
El Factor Inducible por Hipoxia (HIF) es un factor de transcripción que desempeña un papel crucial en las respuestas celulares a bajos niveles de oxígeno (hipoxia). La actividad del HIF está regulada estrictamente por las prolil-hidroxilasas de HIF, que dirigen al HIF para su degradación en condiciones normóxicas. Los inhibidores de la prolil-hidroxilasa de HIF pueden estabilizar el HIF, promoviendo la expresión de genes involucrados en la angiogénesis, la eritropoyesis y el metabolismo. Estos inhibidores son de gran interés en el tratamiento de afecciones como la anemia, las enfermedades isquémicas y el cáncer. En CymitQuimica, ofrecemos inhibidores de HIF/prolil-hidroxilasa HIF para apoyar su investigación en biología de la hipoxia, terapia del cáncer y regulación metabólica.
Productos de "HIF / HIF Prolilhidroxilasa"
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HIF-2α-IN-2
CAS:HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).Fórmula:C17H13F2NO4SPureza:99.24%Forma y color:SolidPeso molecular:365.35Ref: TM-T11561
1mg71,00€5mg135,00€10mg178,00€25mg309,00€50mg447,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)149,00€JPHM-2-167
CAS:PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.Fórmula:C30H28N6O2Forma y color:SolidPeso molecular:504.582PHD-IN-1
CAS:PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.Fórmula:C24H23N7O2Pureza:98%Forma y color:SolidPeso molecular:441.49HIF-2α-IN-3
CAS:HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.Fórmula:C12H6ClN5O5Pureza:98.11%Forma y color:SolidPeso molecular:335.66Ref: TM-T11562
1mg115,00€5mg274,00€10mg432,00€25mg845,00€50mg1.293,00€100mg1.768,00€1mL*10mM (DMSO)303,00€HNHA
CAS:HNHA is an inhibitor of HDAC.Fórmula:C17H21NO2SPureza:98.04%Forma y color:SolidPeso molecular:303.42Ref: TM-T21806
1mg44,00€5mg84,00€10mg135,00€25mg279,00€50mg445,00€100mg640,00€200mg879,00€1mL*10mM (DMSO)90,00€Panaxadiol
CAS:Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Fórmula:C30H52O3Pureza:98% - 99.9%Forma y color:SolidPeso molecular:460.73HIF-1α-IN-2
CAS:HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.Fórmula:C21H19N3OSPureza:98.45%Forma y color:SolidPeso molecular:361.46HIF-2α agonist 2
CAS:HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.Fórmula:C13H8Br2N2O2SPureza:98.32%Forma y color:SoildPeso molecular:416.09Albendazole
CAS:Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.Fórmula:C12H15N3O2SPureza:98.21% - 98.76%Forma y color:Colorless Crystals SolidPeso molecular:265.33JNJ-42041935
CAS:JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.Fórmula:C12H6ClF3N4O3Pureza:99.58% - ≥95%Forma y color:SolidPeso molecular:346.65Ref: TM-T3180
1mg40,00€2mg52,00€5mg88,00€10mg119,00€25mg210,00€50mg354,00€100mg567,00€500mg1.198,00€1mL*10mM (DMSO)87,00€Oroxylin A
CAS:Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Fórmula:C16H12O5Pureza:98.72% - 99.55%Forma y color:SolidPeso molecular:284.26PT2399
CAS:PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.Fórmula:C17H10F5NO4SPureza:98.8% - 99.07%Forma y color:SolidPeso molecular:419.32Ref: TM-T12675L
1mg99,00€5mg235,00€10mg354,00€25mg640,00€50mg944,00€100mg1.320,00€1mL*10mM (DMSO)259,00€ML228
CAS:ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.Fórmula:C27H21N5Pureza:99.03%Forma y color:SolidPeso molecular:415.49VHL-IN-1
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α andFórmula:C28H37FN4O4SPureza:98%Forma y color:SolidPeso molecular:544.68Deferoxamine Mesylate
CAS:Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Fórmula:C26H52N6O11SPureza:94.68% - 99.80%Forma y color:SolidPeso molecular:656.79Chlorogenic Acid
CAS:Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.Fórmula:C16H18O9Pureza:98.76% - 99.67%Forma y color:SolidPeso molecular:354.31Minocycline hydrochloride
CAS:Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Fórmula:C23H28ClN3O7Pureza:100% - 99.89%Forma y color:Bright Yellow-Orange Amorphous Solid Crystalline YellowPeso molecular:493.94Glucosamine sulfate
CAS:Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Fórmula:C6H13NO5·H2SO4Pureza:99.64%Forma y color:White CrystalPeso molecular:277.25HIF-2α-IN-1
CAS:HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.Fórmula:C16H8F5NO4SPureza:97.99%Forma y color:SolidPeso molecular:405.3Roxadustat
CAS:Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.Fórmula:C19H16N2O5Pureza:99% - 99.82%Forma y color:SolidPeso molecular:352.34
