HIF / HIF Prolilhidroxilasa
El Factor Inducible por Hipoxia (HIF) es un factor de transcripción que desempeña un papel crucial en las respuestas celulares a bajos niveles de oxígeno (hipoxia). La actividad del HIF está regulada estrictamente por las prolil-hidroxilasas de HIF, que dirigen al HIF para su degradación en condiciones normóxicas. Los inhibidores de la prolil-hidroxilasa de HIF pueden estabilizar el HIF, promoviendo la expresión de genes involucrados en la angiogénesis, la eritropoyesis y el metabolismo. Estos inhibidores son de gran interés en el tratamiento de afecciones como la anemia, las enfermedades isquémicas y el cáncer. En CymitQuimica, ofrecemos inhibidores de HIF/prolil-hidroxilasa HIF para apoyar su investigación en biología de la hipoxia, terapia del cáncer y regulación metabólica.
Productos de "HIF / HIF Prolilhidroxilasa"
Ordenar por
Hydroxycitric acid tripotassium hydrate
CAS:Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.Fórmula:C6H7K3O8Pureza:95%Forma y color:White Solid CrystallinePeso molecular:324.41THS-044
CAS:THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activityFórmula:C11H12F3N3O3Pureza:100%Forma y color:SolidPeso molecular:291.23dencichine
CAS:Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.Fórmula:C5H8N2O5Pureza:≥95%Forma y color:SolidPeso molecular:176.13Ref: TM-TL0001
1mg49,00€5mg97,00€10mg169,00€25mg349,00€50mg520,00€100mg748,00€200mg1.026,00€1mL*10mM (DMSO)106,00€Amifostine trihydrate
CAS:Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Fórmula:C5H15N2O3PS·3H2OPureza:99.71% - 99.80%Forma y color:SolidPeso molecular:268.27EHP-101
CAS:EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.Fórmula:C28H35NO3Pureza:99.22%Forma y color:SolidPeso molecular:433.58Ref: TM-T13289
1mg107,00€5mg227,00€10mg378,00€25mg620,00€50mg868,00€100mg1.169,00€1mL*10mM (DMSO)250,00€IOX4
CAS:IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)Fórmula:C15H16N6O3Pureza:99.97%Forma y color:SolidPeso molecular:328.33LW6
CAS:LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.Fórmula:C26H29NO5Pureza:98.1% - 99.10%Forma y color:SolidPeso molecular:435.51Ref: TM-T3494
2mg47,00€5mg69,00€10mg89,00€25mg183,00€50mg298,00€100mg449,00€500mg938,00€1mL*10mM (DMSO)69,00€1,4-DPCA
CAS:1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibitingFórmula:C13H8N2O3Pureza:97.75%Forma y color:SolidPeso molecular:240.21Ref: TM-T21653
5mg51,00€10mg84,00€25mg153,00€50mg235,00€100mg376,00€200mg553,00€500mg883,00€1mL*10mM (DMSO)57,00€Hydralazine hydrochloride
CAS:Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.Fórmula:C8H9ClN4Pureza:99.1% - 99.86%Forma y color:Yellow Crystals White Crystalline SolidPeso molecular:196.64M1001
CAS:M1001 is a HIF-2α agonist.Fórmula:C17H17N3O2SPureza:98.83%Forma y color:SolidPeso molecular:327.4FM19G11
CAS:FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).Fórmula:C23H17N3O8Pureza:97.28%Forma y color:SolidPeso molecular:463.4Acriflavine Hydrochloride
CAS:Acriflavine HCl is a HIF-1α inhibitor reducing PGK1, VEGF, and HIF-1α levels both in vitro and in vivo.Fórmula:C14H14ClN3Pureza:99.69%Forma y color:SolidPeso molecular:259.73PT-2385
CAS:PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).Fórmula:C17H12F3NO4SPureza:98.69% - 99.55%Forma y color:SolidPeso molecular:383.34Ref: TM-T7848
1mg66,00€2mg87,00€5mg153,00€10mg258,00€25mg411,00€50mg610,00€100mg868,00€1mL*10mM (DMSO)126,00€MK-8617
CAS:MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).Fórmula:C24H21N5O4Pureza:100% - 99.38%Forma y color:SolidPeso molecular:443.45Chloramphenicol
CAS:Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.Fórmula:C11H12Cl2N2O5Pureza:99.6% - 99.84%Forma y color:Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidPeso molecular:323.13AKB-6899
CAS:AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treatedFórmula:C14H11FN2O4Pureza:97.11%Forma y color:SolidPeso molecular:290.25Ref: TM-T29797
1mg74,00€5mg169,00€10mg263,00€25mg455,00€50mg652,00€100mg929,00€1mL*10mM (DMSO)178,00€DMOG
CAS:DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.Fórmula:C6H9NO5Pureza:80.23% - 99.98%Forma y color:SolidPeso molecular:175.14(Rac)-PT2399
CAS:(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).Fórmula:C17H10F5NO4SForma y color:SolidPeso molecular:419.32HIF1-IN-3
CAS:HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFórmula:C26H24N2O3Pureza:99.48%Forma y color:SolidPeso molecular:412.48
