HIF / HIF Prolilhidroxilasa
El Factor Inducible por Hipoxia (HIF) es un factor de transcripción que desempeña un papel crucial en las respuestas celulares a bajos niveles de oxígeno (hipoxia). La actividad del HIF está regulada estrictamente por las prolil-hidroxilasas de HIF, que dirigen al HIF para su degradación en condiciones normóxicas. Los inhibidores de la prolil-hidroxilasa de HIF pueden estabilizar el HIF, promoviendo la expresión de genes involucrados en la angiogénesis, la eritropoyesis y el metabolismo. Estos inhibidores son de gran interés en el tratamiento de afecciones como la anemia, las enfermedades isquémicas y el cáncer. En CymitQuimica, ofrecemos inhibidores de HIF/prolil-hidroxilasa HIF para apoyar su investigación en biología de la hipoxia, terapia del cáncer y regulación metabólica.
Productos de "HIF / HIF Prolilhidroxilasa"
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KC7F2
CAS:KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.Fórmula:C16H16Cl4N2O4S4Pureza:98% - 99.11%Forma y color:SolidPeso molecular:570.38Angiogenesis agent 1
CAS:Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.Fórmula:C20H24O7Pureza:98%Forma y color:SolidPeso molecular:376.4(-)-Hydroxycitric acid lactone
CAS:(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, whichFórmula:C6H6O7Pureza:99.91%Forma y color:SolidPeso molecular:190.11AKBA
CAS:AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.Fórmula:C32H48O5Pureza:97.85% - 99.77%Forma y color:SolidPeso molecular:512.72Ref: TM-T5S1569
1g1.863,00€1mg43,00€5mg88,00€10mg117,00€25mg187,00€50mg279,00€100mg439,00€500mg1.188,00€1mL*10mM (DMSO)143,00€Adaptaquin
CAS:Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].Fórmula:C21H16ClN3O2Pureza:98.35%Forma y color:SolidPeso molecular:377.82PHD2-IN-4
CAS:PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.Fórmula:C21H19N5O3Forma y color:SolidPeso molecular:389.407TM6089
CAS:TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.Fórmula:C13H14N4O3SPureza:99.07%Forma y color:SolidPeso molecular:306.34Ref: TM-T17105
1mg74,00€5mg164,00€10mg239,00€25mg430,00€50mg645,00€100mg940,00€200mg1.264,00€1mL*10mM (DMSO)170,00€Oltipraz
CAS:Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.Fórmula:C8H6N2S3Pureza:100% - 99.56%Forma y color:SolidPeso molecular:226.34UNC6934
CAS:UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.Fórmula:C24H21N5O4Pureza:99.81%Forma y color:SolidPeso molecular:443.45Ref: TM-T9584
1mg86,00€2mg111,00€5mg180,00€10mg283,00€25mg455,00€50mg645,00€100mg882,00€500mg1.758,00€1mL*10mM (DMSO)188,00€Annaosanchun
CAS:Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).Fórmula:C19H32O3Pureza:99.58%Forma y color:SolidPeso molecular:308.46AFP464 free base
CAS:AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.Fórmula:C22H23F3N4O3Pureza:98%Forma y color:SolidPeso molecular:448.44PHD-1-IN-1
CAS:PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).Fórmula:C13H8N4Pureza:99.78%Forma y color:SolidPeso molecular:220.23Daprodustat
CAS:Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.Fórmula:C19H27N3O6Pureza:97% - 99.82%Forma y color:SolidPeso molecular:393.43Ref: TM-T3197
1mg39,00€5mg75,00€10mg111,00€25mg177,00€50mg296,00€100mg439,00€200mg645,00€1mL*10mM (DMSO)90,00€B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFórmula:C20H17ClN4O3Pureza:99.14%Forma y color:SolidPeso molecular:396.83PX-478
CAS:PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Fórmula:C13H20Cl4N2O3Pureza:97% - ≥98%Forma y color:SolidPeso molecular:394.12FG-2216
CAS:FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Fórmula:C12H9ClN2O4Pureza:100% - 99%Forma y color:SolidPeso molecular:280.66
