Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Products of "Sirtuin"
Sort by
Resveratrol
CAS:Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.Formula:C14H12O3Purity:99.53% - 99.9%Color and Shape:Off-White To Tan PowderMolecular weight:228.24Agrimol B
CAS:1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.Formula:C37H46O12Purity:99.06% - ≥95%Color and Shape:SolidMolecular weight:682.753-TYP
CAS:3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.Formula:C7H6N4Purity:100% - 99.16%Color and Shape:SolidMolecular weight:146.15Ref: TM-T4108
5mg57.00€10mg87.00€25mg170.00€50mg261.00€100mg470.00€500mg1,064.00€1mL*10mM (DMSO)57.00€OSS_128167
CAS:OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).Formula:C19H14N2O6Purity:97.47% - 99.25%Color and Shape:SolidMolecular weight:366.32Ref: TM-T4328
1mg46.00€2mg59.00€5mg93.00€10mg117.00€25mg235.00€50mg432.00€100mg638.00€500mg1,359.00€1mL*10mM (DMSO)93.00€MC2184
CAS:MC2184 is the inhibitor of human recombinant SIRT1.Formula:C11H6N2O3Purity:98%Color and Shape:SolidMolecular weight:214.18MDL-800
CAS:MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Formula:C21H16BrCl2FN2O6S2Purity:100%Color and Shape:SolidMolecular weight:626.3BML-278
CAS:BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, andFormula:C24H25NO4Purity:100%Color and Shape:SolidMolecular weight:391.46Selisistat S-enantiomer
CAS:Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.Formula:C13H13ClN2OPurity:99.69%Color and Shape:SolidMolecular weight:248.71Ref: TM-T7058
1mg150.00€2mg215.00€5mg331.00€10mg472.00€25mg753.00€50mg1,074.00€1mL*10mM (DMSO)379.00€CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Formula:C22H15FN4O2SPurity:98.92%Color and Shape:SolidMolecular weight:418.44SIRT-IN-2
CAS:SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).Formula:C15H21N5O3S2Purity:98.26%Color and Shape:SolidMolecular weight:383.49Ref: TM-T12919
1mg97.00€5mg227.00€10mg364.00€25mg620.00€50mg848.00€100mg1,159.00€200mg1,549.00€1mL*10mM (DMSO)250.00€MC3482
CAS:MC3482 is a specific inhibitor of sirtuin5 (SIRT5).Formula:C33H38N4O8Purity:98% - 99.48%Color and Shape:SoildMolecular weight:618.68Ref: TM-T11962
1mg52.00€2mg74.00€5mg111.00€10mg180.00€25mg283.00€50mg445.00€100mg723.00€500mg1,454.00€SIRT5 inhibitor 5
CAS:SIRT5 Inhibitor 5 is a potent substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 0.21 µM, and does not interact with the NAD+-binding pocket [1].Formula:C21H14ClN3O3SPurity:98%Color and Shape:SolidMolecular weight:423.87UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Formula:C16H13N3Purity:99.75%Color and Shape:SolidMolecular weight:247.29Ref: TM-T7679
1mg40.00€5mg81.00€10mg116.00€25mg226.00€50mg324.00€100mg452.00€200mg632.00€1mL*10mM (DMSO)100.00€Nicotinamide riboside
CAS:Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-Formula:C11H15N2O5Purity:98.61% - 99.58%Color and Shape:SolidMolecular weight:255.25Salermide
CAS:Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.Formula:C26H22N2O2Purity:97.09% - 99.55%Color and Shape:SolidMolecular weight:394.47SIRT7 inhibitor 97491
CAS:SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.Formula:C15H12ClN3OPurity:99.79%Color and Shape:SolidMolecular weight:285.73Ref: TM-T39233
1mg96.00€5mg235.00€10mg354.00€25mg597.00€50mg852.00€100mg1,159.00€1mL*10mM (DMSO)259.00€SIRT6 activator 2
CAS:SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Formula:C23H23N3O6Color and Shape:SolidMolecular weight:437.45Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Formula:C30H42O7Purity:98.06% - 99.87%Color and Shape:SolidMolecular weight:514.65AGK2
CAS:AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.Formula:C23H13Cl2N3O2Purity:98.68% - 99.17%Color and Shape:SolidMolecular weight:434.27SIRT2-IN-9
CAS:SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.Formula:C21H22N6OS2Purity:99.5%Color and Shape:SolidMolecular weight:438.57
