Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Products of "Sirtuin"
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SRT 1460
CAS:SRT 1460 is a SIRT1 activator.Formula:C26H29N5O4SPurity:98.25%Color and Shape:SolidMolecular weight:507.6Et-29
CAS:Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.Formula:C34H46N6O6SPurity:98.69%Color and Shape:SolidMolecular weight:666.83Sirt1/2-IN-3
CAS:Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively.Formula:C17H14ClNO4SPurity:98%Color and Shape:SolidMolecular weight:363.82SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Formula:C25H23N7OSPurity:98.84%Color and Shape:SolidMolecular weight:469.56Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Formula:C13H13ClN2OPurity:99.78%Color and Shape:SolidMolecular weight:248.71Ref: TM-T15263
1mg106.00€2mg159.00€5mg259.00€10mg376.00€25mg630.00€50mg880.00€100mg1,169.00€1mL*10mM (DMSO)284.00€Dihydrocoumarin
CAS:Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).Formula:C9H8O2Purity:98.46%Color and Shape:Leaflets Room Temperature (Ntp 1992)Molecular weight:148.16Sirt1/2-IN-2
CAS:Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively.Formula:C18H14N4O3S2Purity:98%Color and Shape:SolidMolecular weight:398.46SIRT6-IN-3
CAS:SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFormula:C21H30Br3ClN6SPurity:98%Color and Shape:SolidMolecular weight:673.73Sirtuin-IN-2
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.Formula:C28H46N8O6SColor and Shape:SolidMolecular weight:622.78SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formula:C22H24N2O9SColor and Shape:SolidMolecular weight:492.5Ginkgolide C
CAS:Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.Formula:C20H24O11Purity:99.71% - 99.98%Color and Shape:White PowderMolecular weight:440.4MC3138
CAS:MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.Formula:C25H25NO6Purity:99.57%Color and Shape:SolidMolecular weight:435.47Ref: TM-T88662
1mg52.00€5mg100.00€10mg156.00€25mg302.00€50mg492.00€100mg749.00€200mg999.00€1mL*10mM (DMSO)105.00€Sirtuin-1 inhibitor 1
CAS:Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Formula:C20H17N3O2Purity:99.1%Color and Shape:SolidMolecular weight:331.37
