Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Products of "Sirtuin"
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Nicotinamide riboside chloride
CAS:NR, also SRT647, is a B3 vitamin form; precursor to NAD+.Formula:C11H15ClN2O5Purity:98.92% - 99.86%Color and Shape:SolidMolecular weight:290.7Scopolin
CAS:Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.Formula:C16H18O9Purity:99.09% - ≥95%Color and Shape:SolidMolecular weight:354.31Tenovin-3
CAS:Tenovin-3 acts as a p53 activator.Formula:C18H21N3OSPurity:100% - ≥95%Color and Shape:SolidMolecular weight:327.44Ref: TM-T1873
1mg60.00€5mg126.00€10mg202.00€25mg432.00€50mg638.00€100mg908.00€500mg1,825.00€1mL*10mM (DMSO)140.00€Inauhzin
CAS:Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).Formula:C25H19N5OS2Purity:97.69% - 99.36%Color and Shape:SolidMolecular weight:469.58Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.Formula:C20H15N3O2SPurity:99.02%Color and Shape:SolidMolecular weight:361.42SRT 2183
CAS:SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).Formula:C27H24N4O2SPurity:97.86%Color and Shape:SolidMolecular weight:468.57Ref: TM-T16932
1mg50.00€2mg72.00€5mg107.00€10mg165.00€25mg283.00€50mg430.00€100mg622.00€1mL*10mM (DMSO)111.00€SJ-106C
SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.Color and Shape:Odour SolidB2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormula:C20H17ClN4O3Purity:99.14%Color and Shape:SolidMolecular weight:396.83AK-1
CAS:AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.Formula:C19H21N3O5SPurity:98.32% - 99.44%Color and Shape:SolidMolecular weight:403.45HSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Purity:98%Color and Shape:Odour SolidEpigenetic factor-IN-1
CAS:Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.Formula:C32H34FN5O6S2Purity:98%Color and Shape:SolidMolecular weight:667.77RK-9123016
CAS:RK-9123016 is a SIRT2 inhibitor.Formula:C16H18N6O3SPurity:100%Color and Shape:SolidMolecular weight:374.424'-bromo-Resveratrol
CAS:4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)Formula:C14H11BrO2Purity:99.00%Color and Shape:SolidMolecular weight:291.14SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Formula:C24H29ClN8O4SPurity:99.93%Color and Shape:SolidMolecular weight:561.06SIRT5 inhibitor 1
CAS:SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.Formula:C31H39FN6O6S2Purity:98.06%Color and Shape:SolidMolecular weight:674.81Ref: TM-T12921
1mg145.00€2mg207.00€5mg354.00€10mg530.00€25mg934.00€50mg1,359.00€100mg1,825.00€1mL*10mM (DMSO)465.00€Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formula:C25H35ClN4O2SPurity:99.36%Color and Shape:SolidMolecular weight:491.09Ref: TM-T8480
1mg39.00€2mg51.00€5mg70.00€10mg88.00€25mg140.00€50mg226.00€100mg376.00€1mL*10mM (DMSO)73.00€Gardenia yellow
CAS:Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.Formula:C44H64O24Purity:98.24% - 98.82%Color and Shape:Orange Yellow To Reddish Yellow PowderMolecular weight:976.96Z26395438
CAS:Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.Formula:C17H15FN2OPurity:99.63%Color and Shape:SolidMolecular weight:282.31Ref: TM-T77653
1mg57.00€2mg81.00€5mg120.00€10mg180.00€25mg329.00€50mg472.00€100mg700.00€500mg1,406.00€WAY-323061
CAS:WAY-323061 is a SIRT2 inhibitor.Formula:C25H21N5O2SPurity:99.33%Color and Shape:SolidMolecular weight:455.53SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Formula:C22H25ClN8O2SPurity:99.68%Color and Shape:SolidMolecular weight:501
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