Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Products of "Sirtuin"
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SIRT2-IN-16
SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).Formula:C55H91N9O15SColor and Shape:SolidMolecular weight:1150.43SIRT-IN-6
CAS:SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.Formula:C7H4ClN3OSColor and Shape:SolidMolecular weight:213.644Thiomyristoyl
CAS:Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.Formula:C34H51N3O3SPurity:99.16%Color and Shape:SolidMolecular weight:581.85Ref: TM-T3447
1mg57.00€2mg77.00€5mg96.00€10mg124.00€25mg227.00€50mg380.00€100mg567.00€1mL*10mM (DMSO)124.00€SIRT6-IN-5
CAS:SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.Formula:C19H14N2O6Purity:98.84%Color and Shape:SolidMolecular weight:366.32E1231
CAS:E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.Formula:C21H21N3O3Purity:98.45%Color and Shape:SolidMolecular weight:363.41Ref: TM-T9106
1mg35.00€5mg73.00€10mg104.00€25mg207.00€50mg329.00€100mg475.00€500mg938.00€1mL*10mM (DMSO)89.00€Sirt2-IN-1
CAS:Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).Formula:C28H27N7O2S2Purity:99.05% - 99.15%Color and Shape:SolidMolecular weight:557.69Ref: TM-T12920
1mg105.00€5mg215.00€10mg340.00€25mg542.00€50mg735.00€100mg938.00€500mg1,882.00€1mL*10mM (DMSO)266.00€Sirt1/2-IN-4
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (Formula:C21H20N4O3S2Purity:98%Color and Shape:SolidMolecular weight:440.54Fisetin
CAS:Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Formula:C15H10O6Purity:94.14% - 98.31%Color and Shape:Yellow To Brown Crystalline PowderMolecular weight:286.24AGK7
CAS:AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.Formula:C23H13Cl2N3O2Purity:98.31%Color and Shape:SolidMolecular weight:434.27SRT 2104
CAS:SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.Formula:C26H24N6O2S2Purity:97.03% - 99.83%Color and Shape:SolidMolecular weight:516.64Ref: TM-T6679
1g1,644.00€1mg46.00€5mg87.00€10mg131.00€25mg230.00€50mg378.00€100mg563.00€200mg805.00€500mg1,225.00€SIRT-IN-1
CAS:SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).Formula:C19H27N5O2SPurity:97.07%Color and Shape:SolidMolecular weight:389.52ADTL-SA1215
CAS:ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.Formula:C26H29I2NO3Purity:99.23%Color and Shape:SolidMolecular weight:657.32Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Formula:C20H23N3O2SPurity:99.33%Color and Shape:SolidMolecular weight:369.48SIRT5 inhibitor 7
CAS:SIRT5 inhibitor 7 (compound 58), a selective and substrate-competitive SIRT5 inhibitor, exhibits anti-inflammatory properties by modulating proteinFormula:C28H32ClN7O3SPurity:99.77%Color and Shape:SolidMolecular weight:582.12MDL-811
CAS:MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),Formula:C25H25BrCl2FN3O5S2Purity:98%Color and Shape:SolidMolecular weight:681.42SPC-180002
CAS:SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.Formula:C18H23NO4Purity:98%Color and Shape:SolidMolecular weight:317.38Sirtuin modulator 1
CAS:Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Formula:C31H32ClN5O2S2Purity:99.1%Color and Shape:SolidMolecular weight:606.2SRT 1720 dihydrochloride
CAS:SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).Formula:C25H25Cl2N7OSPurity:98.43%Color and Shape:SolidMolecular weight:542.48Sirtinol
CAS:Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).Formula:C26H22N2O2Purity:99.52% - 99.96%Color and Shape:SolidMolecular weight:394.47Ref: TM-T6671
2mg43.00€5mg58.00€10mg93.00€25mg178.00€50mg343.00€100mg509.00€500mg1,121.00€1mL*10mM (DMSO)58.00€AK-7
CAS:AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.Formula:C19H21BrN2O3SPurity:98.43% - 99.34%Color and Shape:SolidMolecular weight:437.35Ref: TM-T5490
1mg37.00€2mg49.00€5mg74.00€10mg105.00€25mg187.00€50mg329.00€100mg540.00€1mL*10mM (DMSO)94.00€
