GluR
Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.
Products of "GluR"
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Pomaglumetad methionil
CAS:Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.Formula:C12H20N2O8S2Purity:98%Color and Shape:SolidMolecular weight:384.43NPS2390
CAS:NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)Formula:C19H21N3OPurity:97.13%Color and Shape:SolidMolecular weight:307.39VU6001376
CAS:VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).Formula:C18H14F2N6OSPurity:98%Color and Shape:SolidMolecular weight:400.41Valiglurax
CAS:Valiglurax (VU2957), potent mGlu4 PAM, crosses blood-brain barrier, orally available; promising for Parkinson's treatment.Formula:C16H10F3N5Purity:97.38%Color and Shape:SolidMolecular weight:329.28(S)-AMPA HCl
(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.Formula:C7H11ClN2O4Color and Shape:SolidMolecular weight:222.63LYPLAL1-IN-1
CAS:LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.Formula:C29H29N7O4Purity:98%Color and Shape:SolidMolecular weight:539.59CDPPB
CAS:CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).Formula:C23H16N4OPurity:99.16%Color and Shape:SolidMolecular weight:364.4YM90K
CAS:YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.Formula:C11H8ClN5O4Purity:100%Color and Shape:SolidMolecular weight:309.66ABP688
CAS:ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.Formula:C15H16N2OPurity:97.85%Color and Shape:SolidMolecular weight:240.3VU0652835
CAS:VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).Formula:C16H19N3O3SPurity:98%Color and Shape:SolidMolecular weight:333.41LY339434 HCl
LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA)Formula:C18H20ClNO4Purity:99% - 99.32%Color and Shape:SoildMolecular weight:349.81LY382884
CAS:LY382884 is a selective and potent GluR5 kainate receptor antagonist with anxiolytic activity.LY382884 blocks blockade of mossy fibre LTP induction.Formula:C18H23NO4Purity:98.06% - 98.71%Color and Shape:SolidMolecular weight:317.38CTEP
CAS:CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-foldFormula:C19H13ClF3N3OPurity:99.17%Color and Shape:SolidMolecular weight:391.77Ref: TM-T6457
2mg37.00€5mg52.00€10mg93.00€25mg145.00€50mg256.00€100mg349.00€200mg495.00€1mL*10mM (DMSO)58.00€mGluR3 modulator-1
CAS:1-ethyl-3-morpholin-4-yl tetrahydroisoquinoline: mGluR3 modulator, potential for Parkinson's.Formula:C16H21N3OPurity:98.99%Color and Shape:SolidMolecular weight:271.36VU 0469650
CAS:VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).Formula:C22H28N4OPurity:97.27%Color and Shape:SolidMolecular weight:364.48Ref: TM-T29118
1mg44.00€5mg84.00€10mg114.00€25mg221.00€50mg329.00€100mg490.00€200mg677.00€1mL*10mM (DMSO)95.00€CPCCOEt
CAS:CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1bFormula:C13H13NO4Purity:99.87%Color and Shape:SolidMolecular weight:247.25Ro0711401
CAS:Ro0711401 is an agonist of mGlu1 receptor.Formula:C18H11F3N2O3Purity:97.57%Color and Shape:SolidMolecular weight:360.29(S)-4CPG
CAS:(S)-4CPG ((S)-4-Carboxyphenylglycine) is a competitive mGlu1 receptor antagonist that attenuates nociceptive hypersensitivity and nociceptive abnormalities associated with sciatic nerve constriction injuries in rats, and may be used in the study of neurological disorders.Formula:C9H9NO4Purity:99.96%Color and Shape:SolidMolecular weight:195.17Methoxy-PEPy
CAS:Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.Formula:C13H10N2OPurity:99.20%Color and Shape:SolidMolecular weight:210.23BMT-145027
CAS:BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).Formula:C23H14ClF3N4Purity:99.62%Color and Shape:SolidMolecular weight:438.83
