Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Products of "Sirtuin"
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SirReal2
CAS:SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.Formula:C22H20N4OS2Purity:98.96% - 99.75%Color and Shape:SolidMolecular weight:420.55Ref: TM-T6984
1mg39.00€2mg50.00€5mg79.00€10mg107.00€25mg197.00€50mg311.00€100mg505.00€1mL*10mM (DMSO)90.00€Splitomicin
CAS:Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in aFormula:C13H10O2Purity:98.64% - 99.11%Color and Shape:SolidMolecular weight:198.22Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Formula:C13H13ClN2OPurity:98.53% - 99.79%Color and Shape:SolidMolecular weight:248.71Ref: TM-T6111
5mg50.00€10mg57.00€25mg93.00€50mg140.00€100mg235.00€200mg349.00€500mg565.00€1mL*10mM (DMSO)52.00€WAY-354574
CAS:WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].Formula:C20H23ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:406.93YM-08
CAS:YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Formula:C19H17N3OS2Purity:98%Color and Shape:SolidMolecular weight:367.49Ophiopogonin D'
CAS:Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.Formula:C44H70O16Purity:99.13%Color and Shape:SolidMolecular weight:855.02MIND4-19
CAS:MIND4-19 is an inhibitor of SIRT2 with antitumor activity.Formula:C22H19N3OSPurity:99.9%Color and Shape:SolidMolecular weight:373.47SRT3657
CAS:SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.Formula:C40H54N8O6SPurity:98%Color and Shape:SolidMolecular weight:774.97YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFormula:C19H21BO7Purity:99.47%Color and Shape:SolidMolecular weight:372.18Ref: TM-T9320
2mg40.00€5mg60.00€10mg87.00€25mg180.00€50mg305.00€100mg535.00€200mg690.00€500mg1,074.00€1mL*10mM (DMSO)66.00€SIRT5 inhibitor 3
CAS:SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Formula:C22H12FN3O4Purity:98%Color and Shape:SolidMolecular weight:401.35SIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Color and Shape:Odour SolidJGB1741
CAS:JGB1741, a SIRT1 inhibitor (IC50=15µM), modulates apoptosis markers and p53 acetylation in breast cancer research.Formula:C27H24N2O2SPurity:97.24%Color and Shape:SolidMolecular weight:440.56SIRT5 inhibitor 6
CAS:SIRT5 Inhibitor 6 is a potent, selective, and substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 3.0 μM, and demonstrates therapeutic potential forFormula:C21H28N6O4SPurity:99.82%Color and Shape:SolidMolecular weight:460.55SIRT1-IN-1
CAS:SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Formula:C14H16N2OPurity:99.31%Color and Shape:SolidMolecular weight:228.29Ref: TM-T9648
1mg96.00€5mg202.00€10mg311.00€25mg533.00€50mg747.00€100mg1,017.00€200mg1,359.00€1mL*10mM (DMSO)207.00€Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formula:C19H15N3O2SPurity:99.47%Color and Shape:SolidMolecular weight:349.41Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Formula:C21H16N2O2SPurity:98.47% - 99.83%Color and Shape:SolidMolecular weight:360.43Ref: TM-T4019
1mg40.00€2mg52.00€5mg85.00€10mg124.00€25mg219.00€50mg350.00€100mg522.00€500mg1,130.00€1mL*10mM (DMSO)66.00€Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Formula:C25H34N4O2SPurity:100% - 97.71%Color and Shape:SolidMolecular weight:454.63Ref: TM-T1818
1mg43.00€2mg56.00€5mg77.00€10mg87.00€25mg157.00€50mg230.00€100mg393.00€500mg930.00€1mL*10mM (DMSO)79.00€Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formula:C51H34N6Na6O23S6Purity:97.47% - 99.97%Color and Shape:WhiteMolecular weight:1429.15SIRT1 activator 1
SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.Purity:98%Color and Shape:Odour SolidSRT1720 hydrochloride
CAS:SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).Formula:C25H24ClN7OSPurity:98% - 99.93%Color and Shape:SolidMolecular weight:506.22Ref: TM-T2412
1mg69.00€2mg89.00€5mg139.00€10mg250.00€25mg394.00€50mg562.00€100mg800.00€200mg1,103.00€500mg1,634.00€1mL*10mM (DMSO)221.00€
